HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

(10-methyl-9-anthryl)methyl imidothiocarbamate

a p53 activator with antineoplastic activity; structure in first source

Also Known As:

NSC 146109; NSC-146109; NSC146109; XI 011; XI-011; XI011 cpd

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Anthracenes: 12
    - (10-methyl-9-anthryl)methyl imidothiocarbamate: 4

Experts

1.	Wang, Hongbo: 2 articles (01/2022 - 07/2011)
2.	Yan, Chunhong: 2 articles (01/2022 - 07/2011)
3.	Fu, Fenghua: 1 article (01/2022)
4.	Guo, Mengqi: 1 article (01/2022)
5.	Tian, Jingwei: 1 article (01/2022)
6.	Wang, Yingjie: 1 article (01/2022)
7.	Yang, Yanting: 1 article (01/2022)
8.	Yin, Qikun: 1 article (01/2022)
9.	Yu, Guohua: 1 article (01/2022)
10.	Zhang, Jingwen: 1 article (01/2022)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2023 - "In this study, we evaluated the efficacy of XI-011, a small molecular inhibitor of MDM4, for treating lung fibrosis. " 01/01/2023 - "XI-011 treatment resulted in the resolution of lung fibrosis in mice with no notable impact on normal fibroblast death or the morphology of healthy lungs. "
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2022 - "XI-011 promoted apoptosis of cervical cancer cells via stabilizing p53 and activating its transcription activity. " 01/01/2022 - "In the current study, XI-011 (NSC146109), a small-molecule inhibitor of MDMX, showed robust anti-proliferation activity against several cervical cancer cell lines. "
3.	Neoplasms (Cancer) 11/01/2014 - "XI-011 exerted the highest growth suppression in tumor cells that overexpress MDM4, in which p53 is degraded. " 01/01/2022 - "Moreover, XI-011 inhibited the growth of xenograft tumor in HeLa tumor-bearing mice, as well as enhanced the cytotoxic activity of cisplatin both in vitro and in vivo. "
4.	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/01/2023 - "Based on these findings, we propose that XI-011 might be a promising therapeutic drug candidate for treating pulmonary fibrosis."
5.	Head and Neck Neoplasms (Head and Neck Cancer) 11/01/2014 - "XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer."

Related Drugs and Biologics

1.	(10-methyl-9-anthryl)methyl imidothiocarbamate
2.	Cisplatin (Platino)
3.	nutlin 3