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isoegomaketone

has antineoplastic activity; isolated from Perilla frutescens

Also Known As:

1-(furan-3-yl)-4-methylpent-2-en-1-one

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jeong, Il-Yun: 3 articles (11/2014 - 03/2014)
2.	Lee, Ju-Hye: 3 articles (11/2014 - 03/2014)
3.	Lee, Mi-Kyung: 3 articles (11/2014 - 03/2014)
4.	Seo, Kwon-Il: 3 articles (11/2014 - 03/2014)
5.	Kwon, Soon-Jae: 2 articles (11/2014 - 03/2014)
6.	Moon, Kwang-Deog: 2 articles (11/2014 - 03/2014)
7.	Han, Sung Nim: 1 article (07/2017)
8.	Jin, Chang Hyun: 1 article (07/2017)
9.	Kim, Jin-Baek: 1 article (07/2017)
10.	Nam, Bomi: 1 article (07/2017)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 11/26/2014 - "In this study, isoegomaketone (1) acted as a synergistic TRAIL sensitizer by mediating up-regulation of DR5 expression in primary prostate cancer RC-58T/h/SA#4 cells. " 11/26/2014 - "Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens."
2.	Rheumatoid Arthritis 07/19/2017 - "In this study, we attempted to identify and assess effects of isoegomaketone (IK) isolated from Perilla frutescens var. crispa on the development of rheumatoid arthritis (RA). "
3.	Melanoma (Melanoma, Malignant) 11/01/2014 - "Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway." 03/01/2014 - "We have demonstrated for the first time the mechanism underlying ROS-mediated mitochondria-dependent apoptotic cell death triggered by isoegomaketone (IK) treatment in melanoma cells. "
4.	Virus Diseases (Viral Diseases) 12/15/2022 - "The bioinformatics analysis and network analysis found that these target genes were closely related to the biological processes of isoegomaketone, such as atherosclerotic formation, inflammation, tumor formation, cytotoxicity, bacterial infection, virus infection, and parasite infection. "
5.	Parasitic Diseases (Parasitic Disease) 12/15/2022 - "The bioinformatics analysis and network analysis found that these target genes were closely related to the biological processes of isoegomaketone, such as atherosclerotic formation, inflammation, tumor formation, cytotoxicity, bacterial infection, virus infection, and parasite infection. "

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