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ITB 301

a microtubule depolymerizing agent and antineoplastic agent; structure in first source

Also Known As:

ITB-301; ITB301

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ahmed, Ahmed Ashour: 1 article (10/2011)
2.	Bast, Robert C: 1 article (10/2011)
3.	Fokt, Izabela: 1 article (10/2011)
4.	Goldsmith, Juliet: 1 article (10/2011)
5.	Krzysko, Krystiana A: 1 article (10/2011)
6.	Le, Xiao-Feng: 1 article (10/2011)
7.	Lesyng, Bogdan: 1 article (10/2011)
8.	Priebe, Waldemar: 1 article (10/2011)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 10/01/2011 - "A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer." 10/01/2011 - "In this work, we show that a unique glycoside of genistein, ITB-301, inhibits the proliferation of SKOv3 ovarian cancer cells. "
2.	Neoplasms (Cancer) 10/01/2011 - "Importantly, efflux-mediated drug resistance did not alter the cytotoxic effect of ITB-301 in two independent cancer cell models of drug resistance. " 10/01/2011 - "To investigate the mechanistic basis of the anti-tumor effect of the compound ITB-301. " 10/01/2011 - "These results identify ITB-301 as a novel anti-tubulin agent that could be used in cancers that are multidrug resistant. "

Related Drugs and Biologics

1.	Genistein
2.	Tubulin
3.	Glycosides