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ML 204

modulates both TRPC4 and TRPC5 channels; structure in first source

Also Known As:

ML-204; ML204 cpd

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - ML 204: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - ML 204: 4

Experts

1.	Koivisto, Ari: 2 articles (06/2022 - 11/2015)
2.	Pertovaara, Antti: 2 articles (06/2022 - 11/2015)
3.	Wei, Hong: 2 articles (06/2022 - 11/2015)
4.	Ailanen, Liisa: 1 article (06/2022)
5.	Morales, Miguel: 1 article (06/2022)
6.	Berta, Temugin: 1 article (01/2021)
7.	Cohen, Cinder Faith: 1 article (01/2021)
8.	Lee, Sang Hoon: 1 article (01/2021)
9.	Prudente, Arthur Silveira: 1 article (01/2021)
10.	Sagalajev, Boriss: 1 article (11/2015)

Related Diseases

1.	Hypersensitivity (Allergy) 11/03/2015 - "In the internal capsule, ML-204 had no effect on hypersensitivity or affective-like pain in SNI animals. " 06/14/2022 - "TRPC4/C5 antagonist ML-204 had a weak antihypersensitivity effect that was only in the early phase, whereas TRPC4/C5 antagonist HC-070 had no effect on hypersensitivity induced by netrin-1. "
2.	Visceral Pain 03/14/2014 - "Significantly, ML-204 inhibited visceral pain-related behavior in a dose-dependent manner without noticeable adverse effects. "
3.	Pain (Aches) 11/03/2015 - "In healthy controls, amygdaloid administration of ML-204 failed to influence pain behavior induced by mechanical stimulation or noxious heat. " 11/03/2015 - "Additionally, amygdaloid administration of ML-204 reduced affective-like pain behavior. " 11/03/2015 - "In the internal capsule, ML-204 had no effect on hypersensitivity or affective-like pain in SNI animals. "
4.	Migraine Disorders (Migraine) 01/01/2021 - "Third, we found a significant decrease in CGRP protein levels in the plasma of both male and female mice treated with ML-204, which largely prevented the development of chronic migraine-like behavior. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Netrin-1
3.	HC-070