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des-amino pateamine A des-methyl

anticancer synthetic analog of marine natural product pateamine A; structure in first source

Also Known As:

des-methyl, des-amino pateamine A; DMDA-PatA

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Agoulnik, Sergei: 1 article (05/2009)
2.	Boivin, Roch: 1 article (05/2009)
3.	Chen, Zhihong: 1 article (05/2009)
4.	Du, Hong: 1 article (05/2009)
5.	Jiang, Yimin: 1 article (05/2009)
6.	Kuznetsov, Galina: 1 article (05/2009)
7.	Littlefield, Bruce A: 1 article (05/2009)
8.	Liu, Junke: 1 article (05/2009)
9.	Marsh, Joanne: 1 article (05/2009)
10.	Parent, Lana: 1 article (05/2009)

Related Diseases

1.	Sarcoma (Soft Tissue Sarcoma) 05/01/2009 - "DMDA-PatA retains almost full in vitro potency in P-glycoprotein-overexpressing MES-SA/Dx5-Rx1 human uterine sarcoma cells that are significantly resistant to paclitaxel, suggesting that DMDA-PatA is not a substrate for P-glycoprotein-mediated drug efflux. "
2.	Neoplasms (Cancer) 05/01/2009 - "DMDA-PatA shows potent anticancer activity in several human cancer xenograft models in nude mice, including significant regressions observed in the LOX and MDA-MB-435 melanoma models. " 05/01/2009 - "We report here that des-methyl, des-amino pateamine A (DMDA-PatA), a structurally simplified analogue of the marine natural product pateamine A, has potent antiproliferative activity against a wide variety of human cancer cell lines while showing relatively low cytotoxicity against nonproliferating, quiescent human fibroblasts. "
3.	Melanoma (Melanoma, Malignant) 05/01/2009 - "DMDA-PatA shows potent anticancer activity in several human cancer xenograft models in nude mice, including significant regressions observed in the LOX and MDA-MB-435 melanoma models. "

Related Drugs and Biologics

1.	des-amino pateamine A des-methyl
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Paclitaxel (Taxol)
4.	pateamine A