Nijmegen Breakage Syndrome-Like Disorder

Also Known As:

Microcephaly and Spontaneous Chromosome Instability without Immunodeficiency; RAD50 Deficiency

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Ovarian Epithelial Carcinoma

1.	Alabdullah, Muslim L: 1 article (12/2020)
2.	Alblihy, Adel: 1 article (12/2020)
3.	Algethami, Mashael: 1 article (12/2020)
4.	Madhusudan, Srinivasan: 1 article (12/2020)
5.	Mongan, Nigel P: 1 article (12/2020)
6.	Rakha, Emad A: 1 article (12/2020)
7.	Toss, Michael S: 1 article (12/2020)
8.	Fleming, James C: 1 article (05/2005)
9.	Hohl, Marcel: 1 article (05/2005)
10.	Petrini, John H J: 1 article (05/2005)

Drugs and Important Biological Agents (IBA) related to Nijmegen Breakage Syndrome-Like Disorder:

1.	Biomarkers (Surrogate Marker)IBA 01/01/2023 - "Thus, RAD50 deficiency may be a good biomarker for predicting PARPi response."
2.	Proteins (Proteins, Gene)FDA Link 12/30/2020 - "RAD50 deficiency was associated with better progression free survival (PFS) at the protein (p = 0.006) and transcriptomic level (p < 0.001). "
3.	PlatinumIBA 12/30/2020 - "We provide evidence that RAD50 deficiency is a predictor of platinum sensitivity. " 12/30/2020 - "RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers."
4.	CohesinsIBA 05/01/2005 - "Sister chromatid cohesion was unaffected by Rad50 deficiency, suggesting that molecular bridging required for recombinational DNA repair is qualitatively distinct from cohesin-mediated sister chromatid cohesion."