Familial Cold Autoinflammatory Syndrome 2

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Hereditary Autoinflammatory Diseases: 43
    - Cryopyrin-Associated Periodic Syndromes: 469
      - Familial Cold Autoinflammatory Syndrome 2: 2
Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Vascular Skin Diseases: 528
    - Urticaria: 5489
      - Chronic Urticaria: 2685
        Chronic Inducible Urticaria: 94
        Cryopyrin-Associated Periodic Syndromes: 469
        Familial Cold Autoinflammatory Syndrome 2: 2
      - Cold Urticaria: 208
        Cryopyrin-Associated Periodic Syndromes: 469
        Familial Cold Autoinflammatory Syndrome 2: 2
  - Genetic Skin Diseases: 47
    - Hereditary Autoinflammatory Diseases: 43
      - Cryopyrin-Associated Periodic Syndromes: 469
        Familial Cold Autoinflammatory Syndrome 2: 2
Immune System Diseases: 4321
- Hypersensitivity: 76867
  - Immediate Hypersensitivity: 2249
    - Urticaria: 5489
      - Chronic Urticaria: 2685
        Chronic Inducible Urticaria: 94
        Cryopyrin-Associated Periodic Syndromes: 469
        Familial Cold Autoinflammatory Syndrome 2: 2
      - Cold Urticaria: 208
        Cryopyrin-Associated Periodic Syndromes: 469
        Familial Cold Autoinflammatory Syndrome 2: 2
Signs and Symptoms Pathological Conditions
- Pathologic Processes: 10023
  - Disease Attributes: 18
    - Chronic Disease: 25762
      - Chronic Urticaria: 2685
        Chronic Inducible Urticaria: 94
        Cryopyrin-Associated Periodic Syndromes: 469
        Familial Cold Autoinflammatory Syndrome 2: 2

Related Diseases

1.	Cryopyrin-Associated Periodic Syndromes
2.	Schnitzler Syndrome
3.	Paraproteinemias (Monoclonal Gammopathy)
4.	Leukocytosis (Pleocytosis)
5.	Inflammation (Inflammations)

Experts

1.	Wang, Hui-Fang: 1 article (02/2022)
2.	Davis, Mark D P: 1 article (07/2018)
3.	van der Hilst, Jeroen C H: 1 article (07/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial Cold Autoinflammatory Syndrome 2:

1.	NucleotidesIBA 02/05/2022 - "Nucleotide-binding leucine-rich repeat-containing receptor 12-related autoinflammatory disease (NLRP12-AID) is a newly identified SAID and a rare autosomal dominant disorder caused by mutations in the NLRP12 gene, which is also known as familial cold autoinflammatory syndrome 2 (FCAS2) and mostly occurs in childhood. "
2.	Leucine (L-Leucine)FDA Link 02/05/2022 - "Nucleotide-binding leucine-rich repeat-containing receptor 12-related autoinflammatory disease (NLRP12-AID) is a newly identified SAID and a rare autosomal dominant disorder caused by mutations in the NLRP12 gene, which is also known as familial cold autoinflammatory syndrome 2 (FCAS2) and mostly occurs in childhood. "
3.	C-Reactive ProteinIBA 07/01/2018 - "In patients presenting with a persistent history of recurrent urticarial plaques associated with signs of systemic inflammation including fevers and elevated inflammatory markers (C-reactive protein [CRP]/serum amyloid A, leukocytosis, and negative connective tissue serologies), consideration should be given to autoinflammatory disorders: the 3 cryopyrin-associated periodic syndromes, Schnitzler syndrome, and familial cold autoinflammatory syndrome 2. Serum protein electrophoresis should be checked to rule out an underlying monoclonal gammopathy."
4.	Blood Proteins (Serum Proteins)IBA 07/01/2018 - "In patients presenting with a persistent history of recurrent urticarial plaques associated with signs of systemic inflammation including fevers and elevated inflammatory markers (C-reactive protein [CRP]/serum amyloid A, leukocytosis, and negative connective tissue serologies), consideration should be given to autoinflammatory disorders: the 3 cryopyrin-associated periodic syndromes, Schnitzler syndrome, and familial cold autoinflammatory syndrome 2. Serum protein electrophoresis should be checked to rule out an underlying monoclonal gammopathy."
5.	Serum Amyloid A Protein (Serum Amyloid A)IBA 07/01/2018 - "In patients presenting with a persistent history of recurrent urticarial plaques associated with signs of systemic inflammation including fevers and elevated inflammatory markers (C-reactive protein [CRP]/serum amyloid A, leukocytosis, and negative connective tissue serologies), consideration should be given to autoinflammatory disorders: the 3 cryopyrin-associated periodic syndromes, Schnitzler syndrome, and familial cold autoinflammatory syndrome 2. Serum protein electrophoresis should be checked to rule out an underlying monoclonal gammopathy."