Carney Triad

Gastric (epithelioid) leiomyosarcoma, functioning extraadrenal paraganglioma, and pulmonary chondroma where at least two of the three, usually the gastric and pulmonary tumors, occur in the same patient. OMIM: 604287

Also Known As:

Networked: 18 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Carney-Stratakis Syndrome
3.	Paraganglioma (Paragangliomas)
4.	Extra-Adrenal Paraganglioma (Paraganglioma, Extra Adrenal)
5.	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)

Experts

1.	Stratakis, Constantine A: 5 articles (03/2021 - 08/2014)
2.	Faucz, Fabio R: 3 articles (01/2018 - 08/2014)
3.	Carney, J Aidan: 3 articles (04/2016 - 08/2014)
4.	Pacak, Karel: 2 articles (03/2021 - 04/2016)
5.	Xekouki, Paraskevi: 2 articles (03/2021 - 04/2016)
6.	Wardelmann, E: 2 articles (03/2017 - 10/2006)
7.	Miettinen, Markku: 2 articles (04/2016 - 02/2011)
8.	Agaimy, Abbas: 2 articles (08/2014 - 07/2007)
9.	Hartmann, Arndt: 2 articles (08/2014 - 07/2007)
10.	Gill, Anthony J: 1 article (03/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Carney Triad:

1.	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/01/2018 - "Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome." 04/01/2016 - "Carney triad can be (rarely) associated with germline succinate dehydrogenase defects." 01/01/2021 - "The Carney triad-associated tumors are characterized by a deficiency of the mitochondrial succinate dehydrogenase enzymatic complex. " 12/01/2019 - "There is evidence that succinate dehydrogenase (SDH) deficiency drives neoplasia in patients with Carney triad, and SDHB immunohistochemistry can be used as a surrogate marker to detect SDH deficiency. " 03/28/2021 - "Succinate dehydrogenase deficiency has been associated with several neoplasias, including renal cell carcinoma (RCC) and those associated with hereditary paraganglioma (PGL)/ pheochromocytoma (PHEO) syndromes, Carney dyad, and Carney triad. "
2.	DNA (Deoxyribonucleic Acid)IBA 07/01/2007 - "We evaluated GISTs from three females with incomplete Carney triad for KIT and PDGFRA mutations and studied the DNA by comparative genomic hybridization (CGH). " 08/01/2014 - "Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad."
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/01/2004 - "Getting the GIST of the Carney Triad: growth factors, rare tumors, and cellular respiration."
4.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/01/2015 - "Combined PET/CT by 18F-FDOPA, 18F-FDA, 18F-FDG, and MRI correlation on a patient with Carney triad."
5.	Somatostatin Receptors (Somatostatin Receptor)IBA 12/01/2017 - "68Ga-DOTA-TATE PET/CT for Molecular Imaging of Somatostatin Receptor Expression in Extra-adrenal Paraganglioma in a Case of Complete Carney Triad."
6.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 10/01/2006 - "A new case of Carney triad: gastrointestinal stromal tumours and leiomyoma of the oesophagus do not show activating mutations of KIT and platelet-derived growth factor receptor alpha."
7.	Radioisotopes (Radionuclides)IBA 12/01/2017 - "This case highlights the usefulness of Ga-DOTA-TATE PET/CT for restaging of metastasizing paraganglioma in Carney triad and the option of targeted radionuclide therapy in this entity." 12/01/2017 - "We present the case of a 36-year-old woman with complete Carney triad who underwent a Ga-DOTA-TATE PET/CT scan for restaging of metastasizing extra-adrenal paraganglioma and for evaluation of targeted radionuclide therapy potential. "
8.	Proteins (Proteins, Gene)FDA Link 02/16/2011 - "Recently, Carney Triad and Carney-Stratakis Syndrome -associated GISTs and pediatric GISTs have been shown to have a loss of expression of succinate dehydrogenase subunit B (SDHB), a Krebs cycle/electron transport chain interface protein. "
9.	Oxidoreductases (Dehydrogenase)IBA 03/01/2017 - "If KIT or PDGFRA mutations are lacking, a succinate dehydrogenase (SDH) deficient GIST has to be considered, either hereditary as Carney-Stratakis syndrome or syndromal as part of a Carney triad."
10.	EnzymesIBA 04/01/2014 - "GISTs can be divided according to immunoexpression of the beta subunit of mitochondrial enzyme succinate dehydrogenase (SDHB) to SDHB-positive (encompassing KIT, PDGFRA and NF1 mutated GISTs), and SDHB-deficient GISTs (including Carney-Stratakis syndrome, Carney triad, sporadic pediatric GISTs, and a small subset of sporadic adult GISTs). "

Therapies and Procedures

1.

Therapeutics 12/01/2017 - "This case highlights the usefulness of Ga-DOTA-TATE PET/CT for restaging of metastasizing paraganglioma in Carney triad and the option of targeted radionuclide therapy in this entity." 12/01/2017 - "We present the case of a 36-year-old woman with complete Carney triad who underwent a Ga-DOTA-TATE PET/CT scan for restaging of metastasizing extra-adrenal paraganglioma and for evaluation of targeted radionuclide therapy potential. "