Familial Advanced Sleep-Phase Syndrome

Also Known As:

Advanced Sleep-Phase Syndrome, Familial; Fasps

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Sleep Wake Disorders: 3640
  - Dyssomnias: 27
    - Circadian Rhythm Sleep Disorders: 240
      - Familial Advanced Sleep-Phase Syndrome: 11
- Chronobiology Disorders: 192
  - Circadian Rhythm Sleep Disorders: 240
    - Familial Advanced Sleep-Phase Syndrome: 11
Occupational Diseases: 970
- Circadian Rhythm Sleep Disorders: 240
  - Familial Advanced Sleep-Phase Syndrome: 11
Mental Disorders: 24177
- Sleep Wake Disorders: 3640
  - Dyssomnias: 27
    - Circadian Rhythm Sleep Disorders: 240
      - Familial Advanced Sleep-Phase Syndrome: 11

Related Diseases

1.	Familial Advanced Sleep-Phase Syndrome
2.	CADASIL
3.	Migraine with Aura (Familial Hemiplegic Migraine)
4.	Neoplasms (Cancer)
5.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

Experts

1.	Xu, Y: 2 articles (03/2012 - 01/2007)
2.	Ebisawa, Takashi: 2 articles (06/2007 - 02/2007)
3.	Jones, C R: 2 articles (01/2007 - 02/2001)
4.	Ptácek, L J: 2 articles (01/2007 - 02/2001)
5.	Toh, K L: 2 articles (01/2007 - 02/2001)
6.	Dong, Yue-Hui: 1 article (01/2021)
7.	Li, Sha-Sha: 1 article (01/2021)
8.	Liu, Zhao-Peng: 1 article (01/2021)
9.	Ding, Ning: 1 article (01/2017)
10.	Du, Ping: 1 article (01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial Advanced Sleep-Phase Syndrome:

1.	Casein Kinase I (Casein Kinase 1)IBA 01/12/2007 - "The FASPS hPER2 S662G mutation resulted in PER2 being hypophosphorylated by casein kinase I (CKI) in vitro. " 02/20/2003 - "Screening in the casein kinase I epsilon (CKIepsilon) binding region of hper2, which was previously reported in familial advanced sleep-phase syndrome patients, with polymerase chain reaction amplification revealed four polymorphisms. "
2.	Sucrose (Saccharose)IBA 01/01/2017 - "Additionally, overexpression and RNAi-mediated downregulation of FaMRLK47 resulted in an increase and decrease in sucrose content, respectively, as compared with control fruits, and respectively promoted and inhibited the expression of genes in the sucrose biosynthesis pathway (FaSS and FaSPS). " 05/30/2023 - "Moreover, increased sugar (sucrose, glucose and fructose) contents and decreased firmness and citric acid contents were observed in the overexpressed fruit, which were accompanied by the upregulation of FaSNS, FaSPS, FaCEL1 and FaACL, as well as the downregulation of FaCS. "
3.	CLOCK ProteinsIBA 03/01/2012 - "A mutation (S662G) in the clock protein PERIOD2 (PER2) is responsible for familial advanced sleep phase syndrome in which sleep onset occurs in the early evening and wakefulness occurs in the early morning. "
4.	Casein Kinase IdeltaIBA 02/01/2007 - "Two of the pedigrees of familial ASPS (FASPS) are caused by mutations in clock genes: the S662G mutation in the Per2 gene or the T44A mutation in the casein kinase 1 delta (CK1delta) gene, although these mutations are not found in other pedigrees of FASPS. "
5.	Casein Kinases (Casein Kinase)IBA 04/08/2011 - "Casein kinase 1-dependent phosphorylation of familial advanced sleep phase syndrome-associated residues controls PERIOD 2 stability."
6.	Protein Isoforms (Isoforms)IBA 01/01/2021 - "CK1 isoforms, especially CK1δ and CK1ε have emerged as important therapeutic targets for severe disorders such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), familial advanced sleep phase syndrome and cancer. "
7.	Citric Acid (Citrate)FDA LinkGeneric 05/30/2023 - "Moreover, increased sugar (sucrose, glucose and fructose) contents and decreased firmness and citric acid contents were observed in the overexpressed fruit, which were accompanied by the upregulation of FaSNS, FaSPS, FaCEL1 and FaACL, as well as the downregulation of FaCS. "
8.	Retinaldehyde (Retinal)IBA 04/01/2015 - "Monogenic subtypes include rare familial hemiplegic migraine, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, familial advanced sleep-phase syndrome (FASPS), and retinal vasculopathy with cerebral leukodystrophy. "
9.	Proteins (Proteins, Gene)FDA Link 04/08/2011 - "Importantly, we found that the pool of Ser-662-phosphorylated PER2 proteins was more stable than the pool of total PER2 molecules, implying that the FASPS phosphorylation cluster antagonizes PER2 degradation. "
10.	MelatoninIBA 02/09/2001 - "Familial advanced sleep phase syndrome (FASPS) is an autosomal dominant circadian rhythm variant; affected individuals are "morning larks" with a 4-hour advance of the sleep, temperature, and melatonin rhythms. "