Mitochondrial Complex II Deficiency

Also Known As:

Succinate CoQ Reductase Deficiency

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Inborn Errors Metabolism: 1162
    - Mitochondrial Complex II Deficiency: 4
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Mitochondrial Diseases: 21919
    - Mitochondrial Complex II Deficiency: 4
  - Inborn Errors Metabolism: 1162
    - Mitochondrial Complex II Deficiency: 4
Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Multienzyme Complexes: 8
    - Succinate Cytochrome c Oxidoreductase: 31
      - Electron Transport Complex II: 20
        Mitochondrial Complex II Deficiency: 4
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Succinate Cytochrome c Oxidoreductase: 31
      - Electron Transport Complex II: 20
        Mitochondrial Complex II Deficiency: 4
    - Oxidoreductases Acting on CH-CH Group Donors
      - Electron Transport Complex II: 20
        Mitochondrial Complex II Deficiency: 4
  - Multienzyme Complexes: 8
    - Electron Transport Chain Complex Proteins
      - Electron-Transferring Flavoproteins: 82
        Electron Transport Complex II: 20
        Mitochondrial Complex II Deficiency: 4
      - Succinate Cytochrome c Oxidoreductase: 31
        Electron Transport Complex II: 20
        Mitochondrial Complex II Deficiency: 4
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Related Diseases

1.	Huntington Disease (Huntington's Disease)
2.	Mitochondrial Diseases (Mitochondrial Disease)
3.	Pheochromocytoma
4.	Paraganglioma (Paragangliomas)

Experts

1.	Janssens, Maurice M L: 1 article (08/2008)
2.	Marcus, Marco A E: 1 article (08/2008)
3.	Schnabel, Ronny M: 1 article (08/2008)
4.	Theunissen, Henricus M S: 1 article (08/2008)
5.	Bayley, Jean-Pierre: 1 article (11/2005)
6.	Devilee, Peter: 1 article (11/2005)
7.	Taschner, Peter E M: 1 article (11/2005)
8.	Bizat, Nicolas: 1 article (05/2003)
9.	Boyer, Frédéric: 1 article (05/2003)
10.	Brouillet, Emmanuel: 1 article (05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mitochondrial Complex II Deficiency:

1.	Cannabinoid Receptor AgonistsIBA 05/06/2003 - "In this study, we examined whether a treatment with Delta9-tetrahydrocannabinol, a non-selective cannabinoid receptor agonist, or with SR141716, a selective antagonist for the cannabinoid CB(1) receptor subtype, could affect the toxicity of the complex II reversible inhibitor malonate injected into the striatum, which replicates the mitochondrial complex II deficiency seen in Huntington's disease patients. "
2.	CannabinoidsIBA 05/06/2003 - "In this study, we examined whether a treatment with Delta9-tetrahydrocannabinol, a non-selective cannabinoid receptor agonist, or with SR141716, a selective antagonist for the cannabinoid CB(1) receptor subtype, could affect the toxicity of the complex II reversible inhibitor malonate injected into the striatum, which replicates the mitochondrial complex II deficiency seen in Huntington's disease patients. "
3.	RimonabantIBA 05/06/2003 - "In this study, we examined whether a treatment with Delta9-tetrahydrocannabinol, a non-selective cannabinoid receptor agonist, or with SR141716, a selective antagonist for the cannabinoid CB(1) receptor subtype, could affect the toxicity of the complex II reversible inhibitor malonate injected into the striatum, which replicates the mitochondrial complex II deficiency seen in Huntington's disease patients. "
4.	malonic acid (malonate)IBA 05/06/2003 - "In this study, we examined whether a treatment with Delta9-tetrahydrocannabinol, a non-selective cannabinoid receptor agonist, or with SR141716, a selective antagonist for the cannabinoid CB(1) receptor subtype, could affect the toxicity of the complex II reversible inhibitor malonate injected into the striatum, which replicates the mitochondrial complex II deficiency seen in Huntington's disease patients. "
5.	Succinate Dehydrogenase (Fumarate Reductase)IBA 04/01/2023 - "Succinate dehydrogenase deficiency, also known as mitochondrial complex II deficiency, is a rare inborn error of metabolism, accounting for approximately 2% of mitochondrial disease. " 11/16/2005 - "The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency."
6.	Anesthetics (Anesthetic Agents)IBA 08/01/2008 - "Anesthetic management for a child with mitochondrial complex II deficiency."