Spontaneous Coronary Artery Dissection

A rare cause of MYOCARDIAL INFARCTION that occurs primarily in women with a mean age of 40 years, especially during the POSTPARTUM PERIOD. OMIM: 122455

Also Known As:

Coronary Artery Dissection, Spontaneous

Networked: 240 relevant articles (10 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 91362
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Cardiovascular Abnormalities: 452
    - Congenital Heart Defects: 8917
      - Coronary Vessel Anomalies: 1
        Spontaneous Coronary Artery Dissection: 240

Related Diseases

1.	Myocardial Infarction
2.	Acute Coronary Syndrome
3.	Atherosclerotic Plaque (Atheroma)
4.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
5.	Ventricular Fibrillation

Experts

1.	Saw, Jacqueline: 14 articles (06/2022 - 04/2014)
2.	Tweet, Marysia S: 8 articles (02/2020 - 04/2012)
3.	Alfonso, Fernando: 7 articles (06/2022 - 01/2020)
4.	Gulati, Rajiv: 7 articles (06/2022 - 04/2012)
5.	Buccheri, Dario: 7 articles (12/2021 - 01/2016)
6.	Hayes, Sharonne N: 7 articles (02/2020 - 04/2012)
7.	Cerrato, Enrico: 5 articles (01/2022 - 07/2017)
8.	D'Ascenzo, Fabrizio: 5 articles (01/2022 - 07/2017)
9.	Macaya, Fernando: 5 articles (01/2022 - 07/2017)
10.	Escaned, Javier: 5 articles (12/2021 - 07/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Spontaneous Coronary Artery Dissection:

1.	Phenobarbital (Luminal)FDA Link 11/01/2015 - "Staged inflation: An approach with achievement of optimal luminal gain and reduced rate of spontaneous coronary artery dissection." 07/01/2023 - "Evaluation of his chest pain through coronary angiography revealed luminal radiolucency corresponding to type 1 spontaneous coronary artery dissection (SCAD). " 05/01/2023 - "Coronary angiography demonstrated a type I spontaneous coronary artery dissection (SCAD) of the mid-left anterior descending artery (LAD) without significant coronary artery disease. Diagnostic intravenous ultrasound (IVUS) confirmed a type I SCAD with penumbra and a minimal luminal area of 10 mm2 of the mid-LAD without significant luminal narrowing. " 02/01/2023 - "Spontaneous coronary artery dissection (SCAD) is a non-traumatic separation of the epicardial coronary arterial wall leading to luminal obstruction with subsequent myocardial ischemia and infarction. " 01/01/2018 - "Spontaneous coronary artery dissection can be a fatal event and could be mistaken for atherosclerotic plaque or coronary spasm rather than luminal compression on coronary angiography and intravascular imaging is helpful in this condition."
2.	Prednisone (Sone)FDA LinkGeneric 07/01/2014 - "Currently, there is no specific treatment for eosinophilic coronary monoarteritis, but cyclophosphamide and prednisone have shown positive results in the treatment of spontaneous coronary artery dissection with unspecified periadventitial inflammation. "
3.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 06/01/2022 - "Rationale and design of the BA-SCAD (Beta-blockers and Antiplatelet agents in patients with Spontaneous Coronary Artery Dissection) randomized clinical trial." 06/01/2022 - "The Beta-blockers and Antiplatelet agents in patients with Spontaneous Coronary Artery Dissection (BA-SCAD) is an academic, pragmatic, prospective, randomized, open-label, blinded-endpoint clinical trial, performed under the auspices of the Spanish Society of Cardiology, to assess the efficacy of pharmacological therapy in patients with SCAD. "
4.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/01/2014 - "Currently, there is no specific treatment for eosinophilic coronary monoarteritis, but cyclophosphamide and prednisone have shown positive results in the treatment of spontaneous coronary artery dissection with unspecified periadventitial inflammation. "
5.	Endothelins (Endothelin)IBA 12/01/2019 - "Here, we summarize the main clinical trials using ERAs and discuss the role of endothelin in cardiovascular diseases such as arterial hypertension, preecclampsia, coronary atherosclerosis, myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) caused by spontaneous coronary artery dissection (SCAD), Takotsubo syndrome, and heart failure. "
6.	RNA (Ribonucleic Acid)IBA 01/01/2021 - "The aim of this study was to identify RNA modifications related to spontaneous coronary artery dissection (SCAD). "
7.	Proteins (Proteins, Gene)FDA Link 01/01/2022 - "The aim of this study was to highlight circulating proteins associated with aortic aneurysm and dissection (AAD) and spontaneous coronary artery dissection (SCAD). "
8.	Oral ContraceptivesIBA 01/01/2022 - "Low-Dose Oral Contraceptives and Spontaneous Coronary Artery Dissection With Heavy Clot Burden in a Nonpregnant Woman." 12/01/2013 - "A case of a young, healthy woman with spontaneous coronary artery dissection associated with oral contraceptive use: Long-term residual dissection of the coronary artery." 10/10/2006 - "Spontaneous coronary artery dissection associated with oral contraceptive use: a case report and review of the literature." 02/01/1995 - "Spontaneous coronary artery dissection associated with oral contraceptive use." 01/01/2009 - "Spontaneous coronary artery dissection is an uncommon cause of acute coronary syndrome in young healthy females, with pregnancy and the use of oral contraceptive pills as recognized predisposing factors. "
9.	Biomarkers (Surrogate Marker)IBA 08/01/2019 - "The patient was found to have elevated cardiac biomarkers and was ultimately diagnosed with pregnancy-related spontaneous coronary artery dissection (P-SCAD). " 10/01/2020 - "Case report: spontaneous coronary artery dissection and suspicion of takotsubo cardiomyopathy in a patient presenting with T-wave inversions, severe QTc prolongation, elevated cardiac biomarkers, and apical akinesia." 09/01/2012 - "Spontaneous coronary artery dissection in an elderly woman presenting with chest pain and positive cardiac biomarkers." 04/01/2021 - "Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker."
10.	Hormones (Hormone)IBA 01/01/2020 - "Spontaneous Coronary Artery Dissection and Exogenous Hormone." 10/01/2013 - "Hormone-associated spontaneous coronary artery dissection." 03/01/2023 - "Association between hormone therapy and short-term cardiovascular events in women with spontaneous coronary artery dissection." 01/01/2018 - "These conditions include obstructive coronary artery disease, coronary microvascular dysfunction, spontaneous coronary artery dissection, diseases of the cardiac muscle including heart failure and takotsubo cardiomyopathy, and conditions related to neurovascular dysregulation including hot flashes and night sweats associated with menopause and effects of exogenous hormones on vascular function. "

Therapies and Procedures

1.	Conservative Treatment 07/01/2021 - "Invasive versus conservative management in spontaneous coronary artery dissection: A meta-analysis and meta-regression study." 06/01/2023 - "Conservative management of high-risk spontaneous coronary artery dissection involving the left main coronary artery." 08/01/2021 - "Optical coherence tomography findings of spontaneous coronary artery dissection after conservative treatment." 12/31/2020 - "Post-partum spontaneous coronary artery dissection refractory to conservative management." 09/01/2020 - "Conservative Management of Spontaneous Coronary Artery Dissection."
2.	Drug-Eluting Stents 11/15/2017 - "Letter to "Safety and efficacy of drug eluting stents in patients with spontaneous coronary artery dissection" by Conrotto F et al." 07/01/2017 - "Safety and efficacy of drug eluting stents in patients with spontaneous coronary artery dissection." 07/01/2017 - "Given the different pathogenesis, use of drug eluting stent (DES) in patients with Spontaneous Coronary Artery Dissection SCAD may delay the healing of the dissected vessel. " 03/01/2014 - "Optical coherence tomogram of spontaneous coronary artery dissection managed with drug eluting stent." 04/01/2009 - "Multivessel spontaneous coronary artery dissection in a postpartum woman treated with multiple drug-eluting stents."
3.	Therapeutics 01/01/2022 - "DISCO study suggests that less is more regarding antiplatelet therapy in spontaneous coronary artery dissection." 11/01/2022 - "A CT coronary angiogram (CTCA) diagnosed spontaneous coronary artery dissection (SCAD) of the right coronary artery, which was successfully managed with medical therapy. " 01/01/2022 - "The Conundrum of Anticoagulation and Antiplatelet Therapy in Spontaneous Coronary Artery Dissection." 01/01/2022 - "Dual antiplatelet therapy analysis inconclusive in DISCO registry for spontaneous coronary artery dissection." 12/28/2021 - "Corrigendum to: Antiplatelet therapy in patients with conservatively managed spontaneous coronary artery dissection from the multicentre DISCO registry."
4.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 10/01/2022 - "Previous studies have not shown the efficacy of implantable cardioverter defibrillators (ICDs) for spontaneous coronary artery dissection (SCAD). " 10/01/2022 - "Subcutaneous implantable cardioverter defibrillator for spontaneous coronary artery dissection with ventricular fibrillation: A report of two cases." 01/01/2021 - "Implantable cardioverter-defibrillator in patients with spontaneous coronary artery dissection presenting with sudden cardiac arrest." 01/01/2020 - "Implantable cardioverter defibrillator therapy for secondary prevention in spontaneous coronary artery dissection: to place or not to place? " 10/01/2022 - "The efficacy of implantable cardioverter defibrillators (ICDs) for secondary prevention in spontaneous coronary artery dissection (SCAD) with ventricular fibrillation (VF) remains unclear. "
5.	Stents 08/01/2021 - "Unusual interventional treatment of spontaneous coronary artery dissection without stent implantation: a case series." 05/03/2021 - "Stent Embolization in Spontaneous Coronary Artery Dissection and Its Deployment at the Right Radial Artery." 08/01/2019 - "Spontaneous coronary artery dissection: "To stent or not to stent, that is the question"." 08/01/2019 - "A case report of spontaneous coronary artery dissection complicated by stent fracture." 07/01/2019 - "Successful Coronary Flow Restoration by Stent-Free Strategy Using the Pull-Back Method of Cutting Balloon in Spontaneous Coronary Artery Dissection."