Primary Failure of Tooth Eruption

Also Known As:

Failure of Tooth Eruption, Primary; Dental Noneruption; Posterior Openbite, Familial; Primary Failure of Eruption, Nonsyndromic; Primary Retention of Teeth; Unerupted Second Primary Molar

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Stomatognathic Diseases: 705
- Tooth Diseases: 33
  - Primary Failure of Tooth Eruption: 6

Experts

1.	Dean, Thomas: 1 article (06/2022)
2.	Gardella, Thomas J: 1 article (06/2022)
3.	Jüppner, Harald: 1 article (06/2022)
4.	Khatri, Ashok: 1 article (06/2022)
5.	Portales-Castillo, Ignacio: 1 article (06/2022)
6.	Albalawi, Alia M: 1 article (11/2019)
7.	Almatrafi, Ahmed: 1 article (11/2019)
8.	Assiry, Ali A: 1 article (11/2019)
9.	Basit, Sulman: 1 article (11/2019)
10.	Khan, Siraj D: 1 article (11/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Primary Failure of Tooth Eruption:

1.	Type 1 Parathyroid Hormone Receptor (Parathyroid Hormone Receptor)IBA 01/01/2016 - "Primary failure of tooth eruption (PFE) is causally linked to heterozygous mutations of the parathyroid hormone receptor (PTH1R) gene. " 01/01/2013 - "Primary Failure of tooth Eruption (PFE) is a non-syndromic disorder which can be caused by mutations in the parathyroid hormone receptor 1 gene (PTH1R). "
2.	GTP-Binding Proteins (G-Protein)IBA 01/01/2016 - "PTH1R Mutants Found in Patients with Primary Failure of Tooth Eruption Disrupt G-Protein Signaling."
3.	Proteins (Proteins, Gene)FDA Link 01/01/2019 - "PPR deficiency induced a cell fate shift of PTHrP+ DF mesenchymal progenitor cells to nonphysiological cementoblast-like cells precociously forming the cellular cementum on the root surface associated with up-regulation of Mef2c and matrix proteins, resulting in loss of the proper periodontal attachment apparatus and primary failure of tooth eruption, closely resembling human genetic conditions caused by PPR mutations. "
4.	Parathyroid Hormone (Parathormone)IBA 06/01/2022 - "Consistent with a vital role of parathyroid hormone (PTH) receptor type 1 (PTH1R) in skeletal development, homozygous loss-of-function PTH1R mutations in humans results in neonatal lethality (Blomstrand chondrodysplasia), whereas such heterozygous mutations cause a primary failure of tooth eruption (PFE). "
5.	Histone MethyltransferasesIBA 11/11/2019 - "KMT2C, a histone methyltransferase, is mutated in a family segregating non-syndromic primary failure of tooth eruption."

Therapies and Procedures

1.	Orthodontics 11/02/2023 - "The databases PubMed, Science Direct, Scopus, and Web of Science were searched from 1 July 2013 to 1 July 2023, using keywords "primary failure of tooth eruption" OR "primary failure of eruption" OR "tooth eruption failure" OR "PFE" AND "orthodontics". "