Severe Early-Onset Chronic Obstructive Pulmonary Disease

Susceptibility for severe early onset COPD has been mapped to chromosome 2. OMIM: 606963

Also Known As:

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset; COPD, Severe Early-Onset

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Respiratory Tract Diseases: 6015
- Lung Diseases: 22246
  - Obstructive Lung Diseases: 1731
    - Chronic Obstructive Pulmonary Disease: 40532
      - Severe Early-Onset Chronic Obstructive Pulmonary Disease: 4
Signs and Symptoms Pathological Conditions
- Pathologic Processes: 10023
  - Disease Attributes: 18
    - Chronic Disease: 25762
      - Chronic Obstructive Pulmonary Disease: 40532
        Severe Early-Onset Chronic Obstructive Pulmonary Disease: 4

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD)

Experts

1.	Litonjua, Augusto A: 2 articles (06/2009 - 10/2005)
2.	Raby, Benjamin A: 2 articles (06/2009 - 10/2005)
3.	Silverman, Edwin K: 2 articles (06/2009 - 10/2005)
4.	Cho, Michael H: 1 article (06/2009)
5.	Ciulla, Dawn M: 1 article (06/2009)
6.	Hersh, Craig P: 1 article (06/2009)
7.	Klanderman, Barbara J: 1 article (06/2009)
8.	Sparrow, David: 1 article (06/2009)
9.	DeMeo, D L: 1 article (12/2007)
10.	Foreman, M G: 1 article (12/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Severe Early-Onset Chronic Obstructive Pulmonary Disease:

1.	ElastinIBA 06/01/2009 - "Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease." 10/01/2005 - "A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease." 10/01/2005 - "We describe a novel variant in the terminal exon of human elastin, c.2318 G > A, resulting in an amino acid substitution of glycine 773 to aspartate (G773D) in a pedigree with severe early-onset chronic obstructive pulmonary disease (COPD). "
2.	SmokeIBA 12/01/2007 - "In conclusion, passive smoke exposure increases morbidity in severe early-onset chronic obstructive pulmonary disease probands, and chronic obstructive pulmonary disease exacerbations correlate with chronic sputum production in probands and relatives. "
3.	Immunoglobulin E (IgE)IBA 11/01/1999 - "Therefore, bronchodilator responsiveness and total serum immunoglobulin E(IgE) levels were assessed in 184 adult first-degree relatives of probands with severe early-onset chronic obstructive pulmonary disease (COPD) and a control group. "
4.	Glycine (Aminoacetic Acid)FDA LinkGeneric 10/01/2005 - "We describe a novel variant in the terminal exon of human elastin, c.2318 G > A, resulting in an amino acid substitution of glycine 773 to aspartate (G773D) in a pedigree with severe early-onset chronic obstructive pulmonary disease (COPD). "
5.	Bronchodilator Agents (Bronchodilators)IBA 11/01/1999 - "Therefore, bronchodilator responsiveness and total serum immunoglobulin E(IgE) levels were assessed in 184 adult first-degree relatives of probands with severe early-onset chronic obstructive pulmonary disease (COPD) and a control group. "
6.	Aspartic Acid (Aspartate)FDA Link 10/01/2005 - "We describe a novel variant in the terminal exon of human elastin, c.2318 G > A, resulting in an amino acid substitution of glycine 773 to aspartate (G773D) in a pedigree with severe early-onset chronic obstructive pulmonary disease (COPD). "