Autosomal Recessive Colorectal Adenomatous Polyposis

mutation in MUTYH

Also Known As:

Colorectal Adenomatous Polyposis, Autosomal Recessive; Adenomas, Multiple Colorectal, Autosomal Recessive

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
Digestive System Diseases: 1042
- Gastrointestinal Diseases: 5874
  - Gastrointestinal Neoplasms: 4373
    - Intestinal Neoplasms: 523
      - Colorectal Neoplasms: 73999
        Adenomatous Polyposis Coli: 3446
        Autosomal Recessive Colorectal Adenomatous Polyposis: 1
  - Intestinal Diseases: 1601
- Digestive System Neoplasms: 236
  - Gastrointestinal Neoplasms: 4373
    - Intestinal Neoplasms: 523
      - Colorectal Neoplasms: 73999
        Adenomatous Polyposis Coli: 3446
        Autosomal Recessive Colorectal Adenomatous Polyposis: 1
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Hereditary Neoplastic Syndromes: 112
    - Adenomatous Polyposis Coli: 3446
      - Autosomal Recessive Colorectal Adenomatous Polyposis: 1

Experts

1.	Nakabeppu, Yusaku: 1 article (04/2006)
2.	Nakatsu, Yoshimichi: 1 article (04/2006)
3.	Sakamoto, Katsumi: 1 article (04/2006)
4.	Sakumi, Kunihiko: 1 article (04/2006)
5.	Tsuchimoto, Daisuke: 1 article (04/2006)
6.	Tsuzuki, Teruhisa: 1 article (04/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Autosomal Recessive Colorectal Adenomatous Polyposis:

1.	GuanineIBA 04/01/2006 - "MUTYH deficiency may also increase G:C to T:A transversions through the misincorporation of 2-OH-dATP, especially in the intestinal tract, since MUTYH can excise 2-hydroxyadenine opposite guanine in genomic DNA and the repair activity is selectively impaired by a mutation found in patients with autosomal recessive colorectal adenomatous polyposis."
2.	DNA (Deoxyribonucleic Acid)IBA 04/01/2006 - "MUTYH deficiency may also increase G:C to T:A transversions through the misincorporation of 2-OH-dATP, especially in the intestinal tract, since MUTYH can excise 2-hydroxyadenine opposite guanine in genomic DNA and the repair activity is selectively impaired by a mutation found in patients with autosomal recessive colorectal adenomatous polyposis."
3.	2-hydroxydeoxyadenosine triphosphateIBA 04/01/2006 - "MUTYH deficiency may also increase G:C to T:A transversions through the misincorporation of 2-OH-dATP, especially in the intestinal tract, since MUTYH can excise 2-hydroxyadenine opposite guanine in genomic DNA and the repair activity is selectively impaired by a mutation found in patients with autosomal recessive colorectal adenomatous polyposis."
4.	isoguanineIBA 04/01/2006 - "MUTYH deficiency may also increase G:C to T:A transversions through the misincorporation of 2-OH-dATP, especially in the intestinal tract, since MUTYH can excise 2-hydroxyadenine opposite guanine in genomic DNA and the repair activity is selectively impaired by a mutation found in patients with autosomal recessive colorectal adenomatous polyposis."