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Complementation Group I Fanconi Anemia

mutation in FANCI

Also Known As:

Fanconi Anemia, Complementation Group I

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Experts

1.	Li, Lei: 1 article (01/2020)
2.	Li, Qing: 1 article (01/2020)
3.	Liu, DePing: 1 article (01/2020)
4.	Meng, LingBing: 1 article (01/2020)
5.	Zheng, Pengchao: 1 article (01/2020)
6.	Birkbak, N J: 1 article (01/2018)
7.	Bowman-Colin, C: 1 article (01/2018)
8.	Diossy, M: 1 article (01/2018)
9.	Dreze, M: 1 article (01/2018)
10.	Garber, J E: 1 article (01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Complementation Group I Fanconi Anemia:

1.	Proteins (Proteins, Gene)FDA Link 01/01/2020 - "Fanconi anemia complementation group I (FANCI) is a key protein in ribosome biogenesis and DNA repair. " 09/04/2009 - "In this study, we report that the purified wild-type FANCI (Fanconi anemia complementation group I) protein directly binds to a variety of DNA substrates. " 01/01/2020 - "The expression of nine genes [polo-like kinase 4 (PLK4), centromere protein U, kinesin family member 20B, structural maintenance of chromosome 2 (SMC2), abnormal spindle microtubule assembly, Fanconi Anemia complementation group I, kinesin family member 18A, spindle apparatus coiled-coil protein 1, and MIS18 binding protein 1] was elevated in PAH; this was statistically significant compared with their expression in healthy lung tissue, and they were identified as hub genes. "
2.	DNA (Deoxyribonucleic Acid)IBA 09/04/2009 - "In this study, we report that the purified wild-type FANCI (Fanconi anemia complementation group I) protein directly binds to a variety of DNA substrates. " 01/01/2018 - "We identified two genes, the Bloom helicase (BLM) and Fanconi anemia complementation group I (FANCI), that have both increased DNA copy number and gene expression in the platinum-sensitive cases. "
3.	KinesinsIBA 01/01/2020 - "The expression of nine genes [polo-like kinase 4 (PLK4), centromere protein U, kinesin family member 20B, structural maintenance of chromosome 2 (SMC2), abnormal spindle microtubule assembly, Fanconi Anemia complementation group I, kinesin family member 18A, spindle apparatus coiled-coil protein 1, and MIS18 binding protein 1] was elevated in PAH; this was statistically significant compared with their expression in healthy lung tissue, and they were identified as hub genes. "
4.	PlatinumIBA 01/01/2018 - "We identified two genes, the Bloom helicase (BLM) and Fanconi anemia complementation group I (FANCI), that have both increased DNA copy number and gene expression in the platinum-sensitive cases. "
5.	Phosphotransferases (Kinase)IBA 01/01/2020 - "The expression of nine genes [polo-like kinase 4 (PLK4), centromere protein U, kinesin family member 20B, structural maintenance of chromosome 2 (SMC2), abnormal spindle microtubule assembly, Fanconi Anemia complementation group I, kinesin family member 18A, spindle apparatus coiled-coil protein 1, and MIS18 binding protein 1] was elevated in PAH; this was statistically significant compared with their expression in healthy lung tissue, and they were identified as hub genes. "
6.	Carrier Proteins (Binding Protein)IBA 01/01/2020 - "The expression of nine genes [polo-like kinase 4 (PLK4), centromere protein U, kinesin family member 20B, structural maintenance of chromosome 2 (SMC2), abnormal spindle microtubule assembly, Fanconi Anemia complementation group I, kinesin family member 18A, spindle apparatus coiled-coil protein 1, and MIS18 binding protein 1] was elevated in PAH; this was statistically significant compared with their expression in healthy lung tissue, and they were identified as hub genes. "
7.	Bloom syndrome proteinIBA 01/01/2018 - "We identified two genes, the Bloom helicase (BLM) and Fanconi anemia complementation group I (FANCI), that have both increased DNA copy number and gene expression in the platinum-sensitive cases. "