Type 2A2 Axonal Charcot-Marie-Tooth Disease

PROM

Also Known As:

Charcot-Marie-Tooth Disease, Axonal, Type 2A2; CMT2A2; Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2A2; Charcot-Marie-Tooth Disease, Neuronal, Type 2A2; Charcot-Marie-Tooth Neuropathy, Type 2A2; HMSN2A2; HMSNIIA2; Hereditary Motor And Sensory Neuropathy IIA2

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Vocal Cord Paralysis
2.	Sphingolipidoses (Sphingolipidosis)
3.	Peripheral Nervous System Diseases (PNS Diseases)
4.	Optic Atrophy
5.	Friedreich Ataxia (Friedreich's Ataxia)

Experts

1.	A Ismail, Mohammad: 1 article (01/2022)
2.	Ababneh, Nidaa A: 1 article (01/2022)
3.	Abdulelah, Ahmed A: 1 article (01/2022)
4.	Al-Kurdi, Ban: 1 article (01/2022)
5.	Ali, Dema: 1 article (01/2022)
6.	Awidi, Abdalla: 1 article (01/2022)
7.	Barham, Raghda: 1 article (01/2022)
8.	Hadidi, Sabal Al: 1 article (01/2022)
9.	Hassona, Yazan: 1 article (01/2022)
10.	Madadha, Adan: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Type 2A2 Axonal Charcot-Marie-Tooth Disease:

1.	Proteins (Proteins, Gene)FDA Link 07/01/2013 - "CMT2A2 is associated with mutations in the mitofusin 2 gene, which encodes a protein involved in mitochondrial fusion. "
2.	IronIBA 04/01/2013 - "Most frequent in this group are mtDNA mutations, inherited peripheral neuropathies, Charcot-Marie-Tooth disorders (CMT2A2, CMTX5), hereditary sensory neuropathy type 3 (HSAN3), Friedreich's ataxia, leukodystrophies, sphingolipidoses, ceroid-lipofuscinoses and neurodegeneration with brain iron accumulation. "
3.	Ethambutol (Myambutol)FDA LinkGeneric 07/01/2013 - "This case shows that patients with CMT2A2, and possibly other mitochondrial fusion defects, may be uniquely susceptible to ethambutol-induced neurotoxicity. " 07/01/2013 - "Ethambutol toxicity exacerbating the phenotype of CMT2A2." 07/01/2013 - "We describe a patient with CMT2A2 (MFN2 mutation: T669G, F223L) who developed accelerated weakness, vocal cord paralysis, and optic atrophy after receiving ethambutol. "
4.	Mitochondrial DNA (mtDNA)IBA 04/01/2013 - "Most frequent in this group are mtDNA mutations, inherited peripheral neuropathies, Charcot-Marie-Tooth disorders (CMT2A2, CMTX5), hereditary sensory neuropathy type 3 (HSAN3), Friedreich's ataxia, leukodystrophies, sphingolipidoses, ceroid-lipofuscinoses and neurodegeneration with brain iron accumulation. "
5.	CeroidIBA 04/01/2013 - "Most frequent in this group are mtDNA mutations, inherited peripheral neuropathies, Charcot-Marie-Tooth disorders (CMT2A2, CMTX5), hereditary sensory neuropathy type 3 (HSAN3), Friedreich's ataxia, leukodystrophies, sphingolipidoses, ceroid-lipofuscinoses and neurodegeneration with brain iron accumulation. "