Calcium Oxalate Nephrolithiasis

Nephrolithiasis that is due to HYPEROXALURIA and increased intestinal absorption of CALCIUM OXALATE and is responsible for 75% of UROLITHIASIS cases. This disorder shows significant heritability. OMIM: 167030

Also Known As:

Networked: 162 relevant articles (3 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperoxaluria (Oxaluria)
2.	Urolithiasis
3.	Osteoporosis
4.	Body Weight (Weight, Body)
5.	Hypercalciuria

Experts

1.	Khan, Saeed R: 6 articles (09/2014 - 09/2002)
2.	Assimos, Dean G: 3 articles (11/2019 - 01/2016)
3.	Eisner, Brian H: 3 articles (04/2016 - 03/2009)
4.	Bozkirli, Ibrahim: 3 articles (11/2011 - 02/2009)
5.	Camtosun, Ahmet: 3 articles (11/2011 - 02/2009)
6.	Ergun, Mehmet Ali: 3 articles (11/2011 - 02/2009)
7.	Onaran, Metin: 3 articles (11/2011 - 02/2009)
8.	Sen, Ilker: 3 articles (11/2011 - 02/2009)
9.	Yilmaz, Akin: 3 articles (11/2011 - 02/2009)
10.	Glenton, Patricia A: 3 articles (09/2010 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Calcium Oxalate Nephrolithiasis:

1.	OxalatesIBA 10/01/1991 - "Further study of oxalate transport of both kidney and intestine will be required to elucidate an etiology of calcium oxalate nephrolithiasis." 03/01/2010 - "Medical prevention and management of calcium oxalate nephrolithiasis will require a comprehensive understanding of oxalate metabolism in humans. " 03/01/2008 - "The mammalian intestine has an important role in the dynamics of oxalate exchange and thereby is significant in the etiology of calcium oxalate nephrolithiasis. " 11/01/2007 - "Dietary oxalate and calcium oxalate nephrolithiasis." 10/01/2005 - "Oxalate-induced tissue damage may play an initiating role in the pathophysiology of calcium oxalate nephrolithiasis. "
2.	CalciumIBA 01/01/2021 - "[Determination of calcium metabolism markers concentration in patients with calcium oxalate nephrolithiasis]." 05/01/2004 - "Calcium supplement should be taken with meal in order to avoid increasing the risk of calcium oxalate nephrolithiasis." 01/01/2000 - "Our findings suggest that the alteration in the risk of calcium oxalate nephrolithiasis based on urinary composition is related to the alteration in urinary calcium. " 01/01/1993 - "Renal handling of calcium in hypercalciuric calcium oxalate nephrolithiasis." 05/01/2022 - "Human idiopathic hypercalciuria (IH) is the most common cause of calcium oxalate nephrolithiasis with perturbed calcium metabolism with increased bone resorption and decreased renal calcium reabsorption, which can be phenotype-copied in the genetic hypercalciuric stone-forming (GHS) rat model. "
3.	Calcium OxalateIBA 08/01/2000 - "Randall's plaques are found most frequently in patients with calcium oxalate stones and are most important in the pathogenesis of calcium oxalate nephrolithiasis. " 04/01/1996 - "Normal calcium oxalate crystal growth inhibition in severe calcium oxalate nephrolithiasis." 12/01/1994 - "In 43 patients with recent-onset calcium oxalate nephrolithiasis (25 male, 18 female; age range: 17-61 yr), urine saturation with calcium oxalate (CaOx) was calculated using a computer program (Equil-AT). " 10/01/1985 - "One reason that some people are prone to calcium oxalate nephrolithiasis is that they produce urine that is subnormal in its ability to inhibit the growth of calcium oxalate crystals. " 03/01/1995 - "Calcium oxalate nephrolithiasis in rats requires induction of hyperoxaluria which results in increased urinary calcium oxalate supersaturation. "
4.	Proteins (Proteins, Gene)FDA Link 07/01/2011 - "The urinary protein composition of 17 patients (11 males, 6 females; mean age 45yrs ± 14SD), affected by calcium oxalate nephrolithiasis, was assessed in comparison with 17 healthy subjects. " 07/01/2011 - "We have studied the urinary protein composition of patients affected by calcium oxalate nephrolithiasis in order to discover a biomarker or any predisposing factors. " 07/01/2011 - "[Urinary peptides and calcium oxalate nephrolithiasis, a combined approach: MALDI-TOF mass spectrometry and MicroBCA Protein Assay]." 04/01/2003 - "To investigate the role of sialic acids and cellular matrix proteins as crystal-binding molecules in human calcium-oxalate nephrolithiasis. " 08/17/1991 - "Calcium-oxalate nephrolithiasis is associated with a defect in erythrocyte oxalate self-exchange and an abnormal rate of erythrocyte membrane protein phosphorylation. "
5.	SodiumIBA 11/01/2009 - "Increasing urine sodium does not appear to increase the risk of calcium oxalate nephrolithiasis. " 11/01/2009 - "Impact of urine sodium on urine risk factors for calcium oxalate nephrolithiasis." 03/01/2003 - "In particular, in idiopathic calcium oxalate nephrolithiasis, the importance of sodium restriction in the diet, that should reduce calcium excretion, has been recently shown, limiting the old assumption of the value of dietary calcium restriction; in fact normal or higher calcium intake, binding oxalate in the intestinal tract, seems to confer protection against stone formation. "
6.	Dietary CalciumIBA 03/01/2003 - "In particular, in idiopathic calcium oxalate nephrolithiasis, the importance of sodium restriction in the diet, that should reduce calcium excretion, has been recently shown, limiting the old assumption of the value of dietary calcium restriction; in fact normal or higher calcium intake, binding oxalate in the intestinal tract, seems to confer protection against stone formation. "
7.	MagnesiumIBA 02/01/1993 - "Thus our findings indicate that dispensation of magnesium as MgO can be beneficial against calcium oxalate nephrolithiasis." 06/01/2005 - "Critically evaluate the experimental evidence and clinical trial outcomes as the basis for use of magnesium (Mg) supplements as therapy for calcium oxalate nephrolithiasis. " 06/01/1977 - "[Animal-experiment studies on the effect of magnesium and vitamin B 6 on calcium-oxalate nephrolithiasis]." 04/01/2013 - "[Experimental evidence of magnesium salts for treatment of calcium oxalate nephrolithiasis in an animal model based on sodium oxalate and a cyclooxygenase 2 selective inhibitor]." 01/01/1998 - "The influence of drinking magnesium hydrogen carbonate natural mineral water enriched with potassium citrate on urinary metabolic abnormalities was prospectively studied in 27 patients with recurrent calcium oxalate nephrolithiasis. "
8.	Oxalic Acid (Disodium Oxalate)IBA 07/01/1987 - "[Resorption of oxalic acid in calcium oxalate nephrolithiasis]." 01/01/1987 - "However, it has recently been shown that long-term treatment with piridoxilate may result in overproduction of oxalic acid and in calcium oxalate nephrolithiasis. " 04/01/1982 - "Calcium oxalate nephrolithiasis in rats, induced by single intraperitoneal injection of sodium oxalate, is associated with pathologic changes in the renal papillary tip. " 07/01/1987 - "In 43 healthy reference persons and 54 patients with relapsing calcium oxalate nephrolithiasis the absorption of oxalic acid was measured by means of 14C-oxalic acid. " 04/01/2013 - "[Experimental evidence of magnesium salts for treatment of calcium oxalate nephrolithiasis in an animal model based on sodium oxalate and a cyclooxygenase 2 selective inhibitor]."
9.	SaltsIBA 04/01/2013 - "So, Mg salts prevented development of calcium-oxalate nephrolithiasis in hyperoxaluric rats. " 01/01/2022 - "Standard diet with normal calcium and reduced animal proteins and salt content reduces stone recurrence in calcium oxalate nephrolithiasis. " 04/01/2013 - "[Experimental evidence of magnesium salts for treatment of calcium oxalate nephrolithiasis in an animal model based on sodium oxalate and a cyclooxygenase 2 selective inhibitor]." 01/01/2000 - "More recently, dietary intake by humans of alkalinizing potassium salts has been demonstrated to exert profound beneficial effects on calcium balance, bone mineralization, predisposition to calcium oxalate nephrolithiasis, and overall nitrogen balance. " 02/01/1990 - "The effect of magnesium citrate and magnesium oxide on urinary biochemistry and on the crystallization of calcium salts was examined in 7 normal subjects and 4 patients with recurrent calcium oxalate nephrolithiasis. "
10.	Pyridoxine (Pyridoxin)FDA LinkGeneric 08/01/1987 - "During the last 4 years we collected 27 specimens of calcium oxalate nephrolithiasis in patients receiving long-term treatment with piridoxilate, a drug composed of an equimolar combination of glyoxylate and pyridoxine. " 01/01/2013 - "The study was aimed to evaluation the effect of different magnesium salts and their combinations with pyridoxine on a course of calcium-oxalate nephrolithiasis, which was modeled by adding the sodium oxalate (3% of weight of the diet) and selective cyclooxygenase-2 inhibitor celecoxib at a dose 100 mg/kg body weight to a diet for 4 weeks. " 04/01/2013 - "The purpose of present study was to investigate influence of magnesium (Mg) salts (Mg L-aspartate, Mg chloride) and their combinations with pyridoxine on development of calcium-oxalate nephrolithiasis induced by sodium oxalate (3% diet weight) and celecoxib (100 mg per kg of bodyweight) according to B.C. "

Therapies and Procedures

1.	Sodium-Restricted Diet (Diet, Sodium Restricted) 04/01/2009 - "To assess whether a normal-calcium, low-animal protein, low-salt diet is effective in reducing hyperoxaluria in idiopathic calcium oxalate nephrolithiasis compared with a traditional low-oxalate diet, routinely recommended by clinicians We treated 56 patients with idiopathic calcium oxalate stone formation who presented with mild hyperoxaluria (>40 mg/d) while consuming a free diet with a normal-calcium, low-animal protein, low-salt diet for a 3-month period. "
2.	Therapeutics 02/01/1997 - "This article discusses the rationale that underlies the choice of medical therapy for the various pathophysiologic causes of calcium oxalate nephrolithiasis and the appropriate use of available medications." 04/01/2016 - "Patients were identified with a history of calcium oxalate nephrolithiasis and hypocitraturia who were on potassium citrate therapy for a minimum of 3 months. " 06/01/2005 - "Critically evaluate the experimental evidence and clinical trial outcomes as the basis for use of magnesium (Mg) supplements as therapy for calcium oxalate nephrolithiasis. " 04/01/2016 - "Two previous studies (<10 patients each) have demonstrated that alkali therapy may reduce urine calcium excretion in patients with calcium oxalate nephrolithiasis. " 07/01/2023 - "Compounds such as statins and angiotensin converting enzyme inhibitors are already in use as therapeutics for hypertension and cardio-vascular disease and have previously shown to reduce calcium oxalate nephrolithiasis in rats. "
3.	Gastric Bypass (Roux-en-Y Gastric Bypass) 06/01/2008 - "Roux-en-Y gastric bypass is associated with early increased risk factors for development of calcium oxalate nephrolithiasis." 01/01/2020 - "Laparoscopic Roux-en-Y gastric bypass (LRYGB) is known to increase risk for calcium oxalate nephrolithiasis due to hyperoxaluria; however, nephrolithiasis rates after laparoscopic sleeve gastrectomy (LSG) are not well described. "
4.	Oral Administration 01/01/1991 - "Effects of the oral administration of glycosaminoglycans on cellular abnormalities associated with idiopathic calcium oxalate nephrolithiasis." 04/01/2015 - "The rat Calcium oxalate nephrolithiasis model was induced through the combined oral administration of ethylene glycol and ammonium chloride, which was intervened with EGCG. "
5.	Bariatric Surgery 09/01/2012 - "(ii) Bariatric surgery, the only intervention that facilitates significant weight loss in morbidly obese people, carries a greater risk of calcium oxalate nephrolithiasis. "