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Fleck Corneal Dystrophy

Also Known As:

Corneal Dystrophy, Fleck; Corneal Dystrophy, Francois-Neetens Speckled or Flecked

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Eye Diseases: 3522
- Corneal Diseases: 916
  - Hereditary Corneal Dystrophies: 820
    - Fleck Corneal Dystrophy: 5
- Hereditary Eye Diseases: 18
  - Hereditary Corneal Dystrophies: 820
    - Fleck Corneal Dystrophy: 5
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Hereditary Eye Diseases: 18
    - Hereditary Corneal Dystrophies: 820
      - Fleck Corneal Dystrophy: 5

Related Diseases

1.	Congenital Structural Myopathies (Centronuclear Myopathy)
2.	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)

Experts

1.	Kawasaki, Satoshi: 1 article (01/2012)
2.	Kinoshita, Shigeru: 1 article (01/2012)
3.	Nakagawa, Hiroko: 1 article (01/2012)
4.	Nakai, Yoshihide: 1 article (01/2012)
5.	Nakatsukasa, Mina: 1 article (01/2012)
6.	Shinomiya, Katsuhiko: 1 article (01/2012)
7.	Yamasaki, Kenta: 1 article (01/2012)
8.	Nie, Xin: 1 article (01/2011)
9.	Pan, Fei: 1 article (01/2011)
10.	Yao, Yu-feng: 1 article (01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fleck Corneal Dystrophy:

1.	Proteins (Proteins, Gene)FDA Link 01/01/2012 - "To the best of our knowledge, this is the first study to show that a novel mutation (p.Glu1389AspfsX16) causing the truncation of the PIKFYVE protein causes fleck corneal dystrophy in the Japanese population."
2.	1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)IBA 01/01/2012 - "The phosphoinositide kinase, FYVE finger containing (PIKFYVE) gene has been identified as a gene responsible for fleck corneal dystrophy (FCD). " 01/01/2012 - "A novel mutation (p.Glu1389AspfsX16) of the phosphoinositide kinase, FYVE finger containing gene found in a Japanese patient with fleck corneal dystrophy."
3.	Phosphatidylinositols (Phosphatidylinositol)IBA 01/01/2006 - "The importance of PtdIns(3,5)P(2) for normal cell function is underscored by recent evidence for its involvement in mammalian cell responses to insulin and for PtdIns(3,5)P(2) dysfunction in the human genetic conditions X-linked myotubular myopathy, Type-4B Charcot-Marie-Tooth disease and fleck corneal dystrophy."
4.	Insulin (Novolin)FDA Link 01/01/2006 - "The importance of PtdIns(3,5)P(2) for normal cell function is underscored by recent evidence for its involvement in mammalian cell responses to insulin and for PtdIns(3,5)P(2) dysfunction in the human genetic conditions X-linked myotubular myopathy, Type-4B Charcot-Marie-Tooth disease and fleck corneal dystrophy."
5.	phosphatidylinositol 3-phosphateIBA 08/01/2008 - "Mutations in the gene encoding the PtdIns3P 5-kinase PIP5K3/PIKfyve have been found in patients affected with François-Neetens fleck corneal dystrophy. "
6.	P-2 (P 2)IBA 01/01/2006 - "The importance of PtdIns(3,5)P(2) for normal cell function is underscored by recent evidence for its involvement in mammalian cell responses to insulin and for PtdIns(3,5)P(2) dysfunction in the human genetic conditions X-linked myotubular myopathy, Type-4B Charcot-Marie-Tooth disease and fleck corneal dystrophy."

Therapies and Procedures

1.	Slit Lamp 01/01/2011 - "Slit-lamp biomicroscopy of the Fleck corneal dystrophy revealed that bilateral small grey-white fleck-like or wreath-like opacities were scattered in all layer of the corneal stroma from the center to the periphery, the intervening stroma between the lesions was clear. " 01/01/2011 - "Eighteen eyes with Fleck corneal dystrophy of 9 patients from two unrelated families were examined by slit-lamp biomicroscopy, Cochet-Bonnet esthesiometer and in vivo confocal microscopy. "
2.	Laser In Situ Keratomileusis (LASIK) 12/01/2006 - "In this patient with Fleck corneal dystrophy, corneal clarity and BSCVA were maintained 6 years after bilateral myopic LASIK, suggesting that LASIK does not stimulate visually significant exacerbation of Fleck corneal dystrophy." 12/01/2006 - "To report the outcome of laser in situ keratomileusis (LASIK) in a patient with Fleck corneal dystrophy. " 12/01/2006 - "Outcome of LASIK in fleck corneal dystrophy."