Hypertensive Nephropathy

A hereditary disorder reported in an AFRICAN AMERICAN family. Nearly half of those affected had CHRONIC KIDNEY FAILURE and HYPERTENSION. PROTEINURIA and focal segmental glomerular sclerosis-like lesions (OMIM: 603278) with ARTERIOLE thickening were observed in one patient. Has been mapped to chromosome 9. OMIM: 608026

Networked: 231 relevant articles (18 outcomes, 40 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy)
2.	Hypertension (High Blood Pressure)
3.	Glomerulonephritis
4.	Renal Insufficiency (Renal Failure)
5.	Fibrosis (Cirrhosis)

Experts

1.	Simoni, Jan: 4 articles (03/2013 - 04/2010)
2.	Wesson, Donald E: 4 articles (03/2013 - 04/2010)
3.	Wu, Lihua: 3 articles (05/2021 - 01/2018)
4.	Amann, Kerstin: 3 articles (01/2021 - 10/2008)
5.	Bader, Michael: 3 articles (11/2020 - 02/2014)
6.	Ortiz, Alberto: 3 articles (08/2020 - 04/2010)
7.	Fang, Zhuyuan: 3 articles (01/2020 - 01/2018)
8.	Huang, Xiao R: 3 articles (08/2014 - 07/2003)
9.	Lan, Hui Y: 3 articles (08/2014 - 07/2003)
10.	Zhang, Li: 2 articles (05/2022 - 12/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypertensive Nephropathy:

1.	Antihypertensive Agents (Antihypertensives)IBA 01/01/2022 - "To evaluate the efficacy of HQI combined with antihypertensive drugs in the treatment of hypertensive nephropathy. " 01/01/2020 - "The objective of this systematic review was to evaluate the efficacy of DHI combined with antihypertensive drugs for treatment of hypertensive nephropathy. " 01/01/2022 - "The combination of HQI and antihypertensive drugs is more efficient in improving the related indexes of patients with hypertensive nephropathy than using antihypertensive drugs alone, and a moderate dose of HQI (no more than 30 mL) may benefit more. " 09/01/2021 - "Current single-target antihypertensive drugs are not effective for hypertensive nephropathy, in part due to its less understood mechanism of pathogenesis. " 06/01/2021 - "Taken together, we demonstrated the involvement of abnormal epithelium-like cells growth in glomerular injury during hypertensive nephropathy in SHRs, and firstly showed the positive effects of the anti-hypertensive drug on the progression of epithelium-like cells growth."
2.	Proteins (Proteins, Gene)FDA Link 05/01/2004 - "An increased relative clearance of aChym in the inner cortex of SHR indicates impairment of the charge barrier, which, at least in part, could explain the increased protein excretion in SHR with hypertensive nephropathy." 05/01/2010 - "Study of protein profiling of human urine in diabetic hypertensive nephropathy versus normal healthy controls." 01/01/2019 - "This study revealed an important role for M2 macrophages and the YM1/Chi3l3 protein in hypertensive nephropathy in a mouse model of hypertension. " 05/02/2020 - "They signal via phosphorylation of proteins such as MYPT-1, thereby regulating many key cellular functions including proliferation, motility and viability and the RhoA/ROCK signaling has been shown to be deeply involved in arterial hypertension, cardiovascular-renal remodeling, hypertensive nephropathy and posttransplant hypertension. " 01/01/2008 - "The purpose of this work was to observe the excretion of specific types of urinary proteins and urinary enzymes in elderly essential hypertension patients, for early detection and targeted treatment of hypertensive nephropathy in the elderly. "
3.	SaltsIBA 01/01/2020 - "To determine the effects and molecular mechanisms of CREG in HS diet-induced hypertensive nephropathy, we established a hypertensive nephropathy animal model in Dahl salt-sensitive (SS) rats fed a HS diet (8% NaCl, n = 20) for 8 weeks. " 01/01/2020 - "However, the role of CREG in high-salt (HS) diet-induced hypertensive nephropathy is unclear. " 05/01/2005 - "Histopathologic and biochemical findings indicate that, in the DS rat, salt-induced hypertensive nephropathy is associated with increased oxidative stress. " 09/01/2021 - "QiShenYiQi ameliorates salt-induced hypertensive nephropathy by balancing ADRA1D and SIK1 expression in Dahl salt-sensitive rats." 09/01/2016 - "This can be explained with comparable hyperfiltration of the kidneys at high sodium load and discussed as early sign of hypertensive nephropathy in salt-sensitive individuals. "
4.	NG-Nitroarginine Methyl Ester (L-NAME)IBA 06/01/2016 - "The objective of our study was to determine whether SWT could ameliorate renal repair and favor angiogenesis in L-NAME-induced hypertensive nephropathy in rats. " 11/15/2013 - "Our study indicates a novel protective effect of sitagliptin against L-NAME induced hypertensive nephropathy. " 01/01/2018 - "This study was conducted to investigate the renoprotective effects of aliskiren and valsartan the ARB, either alone or in combination, on hypertensive nephropathy induced by L-NAME. " 11/15/2013 - "The present study was undertaken to assess the possible protective effects of sitagliptin, a dipeptidyl peptidase 4-inhibitor (DPP4), against Nω-nitro-L-arginine methyl ester (L-NAME) induced hypertensive nephropathy in rats. " 11/15/2013 - "Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor."
5.	CreatinineIBA 12/01/2021 - "Hypertensive nephropathy was defined as serum creatinine ≥1.8 mg / dl or  GFR <40 ml / minute. " 03/24/2015 - "In OLT recipients with diabetes or hypertensive nephropathy, conversion to mTORi does not improve renal function but stabilizes plasma levels of creatinine. " 09/01/2012 - "The diagnosis of hypertensive nephropathy and retinopathy was based on spot urine microalbuminuria/creatinine ratio and opthalmoscopy, examination respectively. " 06/01/1996 - "We studied 22 patients, aged 64 to 74 years, who were diagnosed with hypertensive nephropathy (HN), defined as a diastolic blood pressure (DBP) < 95 mm Hg and a basal creatinine clearance (CCr) of 52 +/- 6 ml/min/1.73 m2. " 03/01/1995 - "A high creatinine clearance (suggesting glomerular hyperfiltration) emerged as a clinical diagnostic marker of early hypertensive nephropathy."
6.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 07/27/1999 - "ACE inhibitors are well established in the treatment of arterial hypertension, heart failure and diabetic and/or hypertensive nephropathy with albuminuria. " 01/01/2004 - "Monitoring of the above early markers of renal damage and metabolic shifts is essential for assessing progression of hypertensive nephropathy and control over efficacy of antihypertensive treatment including ACE inhibitors." 02/01/2014 - "Pharmacological modulation of the renal endogenous reparative process (that is, with angiotensin-converting enzyme inhibitors and AT1 angiotensin II receptor blockers), as well as future therapeutic strategies targeted to the renopoietic system, offers interesting perspectives for the management of hypertensive nephropathy. " 10/01/1999 - "The renoprotective actions of angiotensin-converting enzyme (ACE) inhibitors in patients with diabetic and hypertensive nephropathy is well established. " 11/01/2003 - "The African American Study of Kidney Disease and Hypertension provided evidence that an angiotensin-converting enzyme inhibitor-based treatment program is more beneficial than calcium channel blockers and beta blockers in reducing the progression of renal failure in blacks with hypertensive nephropathy. "
7.	Sodium Bicarbonate (Baking Soda)FDA LinkGeneric 08/01/2010 - "Here, we tested if daily oral sodium bicarbonate slowed GFR decline in patients with hypertensive nephropathy with reduced but relatively preserved eGFR (mean 75 ml/min) in a 5-year, prospective, randomized, placebo-controlled, and blinded interventional study. " 08/01/2010 - "Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy." 08/01/2010 - "Thus, our study shows that in hypertensive nephropathy, daily sodium bicarbonate is an effective kidney protective adjunct to blood pressure control along with angiotensin-converting enzyme inhibition." 01/01/2012 - "Thus, a reduction in dietary acid decreased kidney injury in patients with moderately reduced eGFR due to hypertensive nephropathy and that with fruits and vegetables was comparable to sodium bicarbonate. " 01/01/2012 - "As alkali-induced dietary protein decreased kidney injury in animals, we compared the efficacy of alkali-inducing fruits and vegetables with oral sodium bicarbonate to diminish kidney injury in patients with hypertensive nephropathy at stage 1 or 2 estimated GFR. "
8.	Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesIBA 11/15/2013 - "The present study was undertaken to assess the possible protective effects of sitagliptin, a dipeptidyl peptidase 4-inhibitor (DPP4), against Nω-nitro-L-arginine methyl ester (L-NAME) induced hypertensive nephropathy in rats. "
9.	Alprostadil (Muse)FDA LinkGeneric 01/01/2022 - "This is the first meta-analysis to evaluate the efficacy of alprostadil for hypertensive nephropathy, and the results may guide clinical practice." 01/01/2022 - "We performed a meta-analysis to evaluate the efficacy of alprostadil in the treatment of hypertensive nephropathy. " 01/01/2022 - "Alprostadil for hypertensive nephropathy: A systematic review and meta-analysis of randomized controlled trials." 01/01/2022 - "Compared to conventional treatment alone, alprostadil combined with conventional treatment can improve renal function in patients with hypertensive nephropathy more effectively. "
10.	Sitagliptin Phosphate (Januvia)FDA Link 11/15/2013 - "Our study indicates a novel protective effect of sitagliptin against L-NAME induced hypertensive nephropathy. " 11/15/2013 - "The present study was undertaken to assess the possible protective effects of sitagliptin, a dipeptidyl peptidase 4-inhibitor (DPP4), against Nω-nitro-L-arginine methyl ester (L-NAME) induced hypertensive nephropathy in rats. " 11/15/2013 - "Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor."

Therapies and Procedures

1.	Therapeutics 10/01/1984 - "[Efficacy of therapy in the prevention of hypertensive nephropathy]." 05/29/2023 - "Emerging therapies targeting novel disease mechanisms could provide powerful approaches for hypertensive nephropathy management in the future. " 01/01/2022 - "It is supposed to be an important adjuvant therapy for hypertensive nephropathy. " 08/01/2020 - "Correct causality assessment and aetiology-based therapy is a key to the progress of nephrology and it should no longer be accepted that 'hypertensive nephropathy' serves to disguise a suboptimal diagnostic workup. " 01/01/2018 - "These results suggest that therapies aimed at different targets within the RAAS may have additional effects in attenuating structural injury in experimental hypertensive nephropathy."
2.	Renal Dialysis (Hemodialysis) 01/01/2023 - "We report here a patient undergoing hemodialysis for renal failure caused by hypertensive nephropathy who presented multiple UTCs in the right shoulder, left elbow and wrist. " 01/01/1998 - "Since 1993, our 34-year-old female patient was on replacement treatment with hemodialysis for terminal renal failure due to hypertensive nephropathy. " 04/01/2010 - "According to primary renal disorders, the patients undergoing hemodialysis were classified into 4 groups as diabetic nephropathy, hypertensive nephropathy, reflux nephropathy or interstitial nephritis, and others. " 01/01/2014 - "Studies were conducted among hemodialysis (HD) patients with ESRD due to type 2 DM nephropathy, chronic glomerulonephritis, chronic infective tubulointerstitial nephritis, and hypertensive nephropathy as well as in healthy subjects. " 01/01/2014 - "According to primary renal disorders, the patients undergoing hemodialysis (n = 68) were classified into four groups as diabetic nephropathy, hypertensive nephropathy, reflux nephropathy or interstitial nephritis, and renal insufficiency depending on other causative factors. "
3.	Renal Replacement Therapy (Therapies, Renal Replacement) 10/01/2018 - "This study aims investigating the relationship between RI and the measured AKW in chest radiography of the patients with hypertensive nephropathy who do not require renal replacement therapy.This" 01/01/2018 - "Similar analysis was performed in a subpopulation without a history of hypertensive nephropathy and renal replacement therapy. " 01/01/2010 - "Data on incidence of hypertensive nephropathy previously to dialysis are scanty because there are not registries similar to those used for renal replacement therapy. " 01/01/2010 - "Hypertensive nephropathy is the second most common cause for starting renal replacement therapy in Spain with a steady incidence since 1997. "
4.	Injections 10/01/2020 - "The relative randomized controlled trials(RCTs) of Huoxue Huayu Chinese medicine injections on hypertensive nephropathy were retrieved from CNKI, WanFang, VIP, SinoMed, PubMed, Cochrane Library and Web of Science in November 2019. " 10/01/2020 - "The five kinds of Huoxue Huayu Chinese medicine injections combined with conventional Western medicine had significantly advantages in the treatment of hypertensive nephropathy. " 10/01/2020 - "To assess the clinical efficacy of Huoxue Huayu Chinese medicine injections on hypertensive nephropathy by using Network Meta-analysis method. " 10/01/2020 - "[Network Meta-analysis of Huoxue Huayu Chinese medicine injections on hypertensive nephropathy]." 01/01/2021 - "Traditional Chinese Medicine Injections Combined With Antihypertensive Drugs for Hypertensive Nephropathy: A Network Meta-Analysis."
5.	Nephrectomy 07/01/2009 - "To test whether this translates into hypertensive nephropathy (HN), the lymphocyte migration inhibitor was administered to rats following nephrectomy. " 02/26/1953 - "[Hypertensive endocrine secretions of the kidneys; reflections concerning nephrectomies in general and nephrectomies for unilateral hypertensive nephropathy in particular]." 01/01/2022 - "Reduced expression of KLF2 in glomerular endothelial cells due to hypertension was found in both 5/6 nephrectomy mice and patients with hypertensive nephropathy. " 01/01/2022 - "Here, we investigated the role of KLF2 in hypertensive nephropathy by regulating KLF2 expression in human primary glomerular endothelial cells (hPGECs) and evaluating this expression in the kidney tissues of a 5/6 nephrectomy mouse model as well as patients with hypertension. " 12/01/2020 - "Unilateral nephrectomy and subcutaneous infusion of angiotensin II via osmotic mini-pumps were used to induce hypertensive nephropathy in mice. "