Connective Tissue Nevus

Localized dermal malformations (HARMATOMAS) that consist of COLLAGEN; ELASTIC TISSUE; or GLYCOSAMINOGLYCANS. They may be observed on the torso of young children with inherited disorders such as TUBEROUS SCLEROSIS, or as idiopathic isolated lesions. OMIM: 166700

Networked: 17 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Nevus (Nevi)
2.	Angiofibroma
3.	Mucinoses
4.	Tuberous Sclerosis (Bourneville's Disease)
5.	Marfan Syndrome (Marfan's Syndrome)

Experts

1.	Bianchi, Luca: 1 article (10/2021)
2.	Cerroni, Lorenzo: 1 article (10/2021)
3.	Giunta, Alessandro: 1 article (10/2021)
4.	Manfreda, Valeria: 1 article (10/2021)
5.	Teoli, Miriam: 1 article (10/2021)
6.	Bianchelli, Tommaso: 1 article (03/2020)
7.	Brancorsini, Donatella: 1 article (03/2020)
8.	Diotallevi, Federico: 1 article (03/2020)
9.	Guanciarossa, Francesca: 1 article (03/2020)
10.	Martina, Emanuela: 1 article (03/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Connective Tissue Nevus:

1.	CollagenIBA 11/15/2010 - "Histopathologic features confirmed the diagnosis of a connective-tissue nevus that was composed of collagen. " 09/01/1974 - "[Changes of the collagen in the family incidence of connective tissue nevus]." 01/01/2008 - "From this follow-up report we conclude that phacomatosis pigmentokeratotica may be associated with other cutaneous abnormalities such as linear connective tissue nevus of the collagen type and multiple pinhead-sized angioma-like lesions superimposed on the speckled lentiginous nevus. " 06/01/2023 - "Connective tissue nevus is a hamartoma composed of excess amounts of one or several components of the dermis, such as collagen, elastin, and proteoglycans. " 08/17/2014 - "Zosterifom connective tissue nevus is a rare kind of connective tissue nevi composed of collagen, elastin, or glycosaminoglycan, which was first reported by Steiner 1944. "
2.	trans-crotonin (CTN)IBA 03/01/2020 - "We present the case of a 6-year-old male patient with yellowish papules that coalesced to form plaques localized on both thighs and on the upper limbs consistent with a connective tissue nevus (CTN) diagnosis. " 11/01/2017 - "Connective tissue nevus (CTN) is a rare condition of the extracellular matrix components that generally presents as papulae of normal skin colour. " 10/01/1984 - "We report a case of BN coexistent with a large connective-tissue nevus (CTN) on the right shoulder of a 74-year-old man. " 05/01/2003 - "Mucinous nevus is a very rare entity and can be classified as both a cutaneous mucinosis (CM) and a connective tissue nevus (CTN). " 05/01/1991 - "We examined alpha-actin and an angiogenic factor, basic fibroblast growth factor (bFGF), by immunohistochemistry and Western blot analysis in four angiofibromas (AFs) and a connective tissue nevus (CTN) obtained from two patients with tuberous sclerosis (TS). "
3.	Proteoglycans (Proteoglycan)IBA 07/01/2009 - "It may be divided into two histopathologic types: connective tissue nevus of the proteoglycan (CTNP) and combined epidermal-CTNP. " 07/01/2009 - "Combined epidermal-connective tissue nevus of proteoglycan (a type of mucinous nevus): a case report and literature review." 05/01/2003 - "A case of congenital mucinous nevus: a connective tissue nevus of the proteoglycan type." 08/01/2016 - "Two histological subtypes have been described: pure mucinous dermal nevus (connective tissue nevus of the proteoglycan [CTNP]) and combined mucinous nevus (combined CTNP) associating epidermal nevus with dermal mucin deposits. " 06/01/2023 - "Connective tissue nevus is a hamartoma composed of excess amounts of one or several components of the dermis, such as collagen, elastin, and proteoglycans. "
4.	SteroidsIBA 01/01/2018 - "Satisfactory treatment of a large connective tissue nevus with intralesional steroid injection." 10/01/2021 - "Connective tissue nevus in Marfan Syndrome successfully treated with intralesional steroid injections."
5.	MucinsIBA 08/01/2016 - "It belongs to the connective tissue nevus family and is characterized by dermal mucin deposits. " 01/01/2005 - "In contrast with common collagenous connective tissue nevus, it is hard to define the localized persistent mucin accumulation as a nevoid manifestation. " 08/01/2016 - "Two histological subtypes have been described: pure mucinous dermal nevus (connective tissue nevus of the proteoglycan [CTNP]) and combined mucinous nevus (combined CTNP) associating epidermal nevus with dermal mucin deposits. "
6.	ElastinIBA 06/01/2023 - "Connective tissue nevus is a hamartoma composed of excess amounts of one or several components of the dermis, such as collagen, elastin, and proteoglycans. " 08/17/2014 - "Zosterifom connective tissue nevus is a rare kind of connective tissue nevi composed of collagen, elastin, or glycosaminoglycan, which was first reported by Steiner 1944. "
7.	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 05/01/1991 - "We examined alpha-actin and an angiogenic factor, basic fibroblast growth factor (bFGF), by immunohistochemistry and Western blot analysis in four angiofibromas (AFs) and a connective tissue nevus (CTN) obtained from two patients with tuberous sclerosis (TS). "
8.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 05/01/1991 - "We examined alpha-actin and an angiogenic factor, basic fibroblast growth factor (bFGF), by immunohistochemistry and Western blot analysis in four angiofibromas (AFs) and a connective tissue nevus (CTN) obtained from two patients with tuberous sclerosis (TS). "
9.	Trichloroacetic AcidIBA 11/01/2015 - "We report a case of sinus tract development within a connective tissue nevus in a patient with velocardiofacial syndrome and describe our treatment of sinus tracts using surgical deroofing and trichloroacetic acid scarification. "
10.	GlycosaminoglycansIBA 08/17/2014 - "Zosterifom connective tissue nevus is a rare kind of connective tissue nevi composed of collagen, elastin, or glycosaminoglycan, which was first reported by Steiner 1944. "

Therapies and Procedures

1.	Injections 10/01/2021 - "Connective tissue nevus in Marfan Syndrome successfully treated with intralesional steroid injections."