Hyperheparinemia

A congenital susceptibility to hemmorhage due to an excess of clotting inhibitor. The blood clotting defected may be corrected in vitro by PROTAMINE SULFATE and TOLUIDINE BLUE. OMIM: 144050

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Atherosclerosis
3.	Dyslipidemias (Dyslipidemia)
4.	Thrombosis (Thrombus)
5.	Thrombocytopenia (Thrombopenia)

Experts

1.	Gozhenko, A I: 1 article (12/2014)
2.	Kotyuzhinskaya, S G: 1 article (12/2014)
3.	Kovalevskaya, L A: 1 article (12/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperheparinemia:

1.	Heparin (Liquaemin)FDA LinkGeneric 12/31/1954 - "[Physiopathology of heparin; preliminary report; hyperheparinemia and hypoheparinemia in various cardiopathies]." 05/28/1948 - "Similarity to Heparin of the Clotting Inhibitor in Acute Leucemia and the Significance of Hyperheparinemia in Estrapenic Cholinergic States." 10/01/1976 - "Although hyperheparinemia, heparin rebound, and protamine excess have occasionally been incriminated as sources of hemorrhage during CPB, no well documented cases appear in the literature. " 12/01/2014 - "The article describes known atherosclerosis predictors of endothelial origin, which are diagnostic criteria for identifying's early stages of atherosclerosis, and can prevent the development of this disease and are used to monitor the effectiveness of the therapy The authors analyzed the possibility of using heparin as an early marker of atherosclerosis, based on the fact that the inhibition of lipoprotein lipase activity due hyperheparinemia resulting from depletion of mast cells due to endothelial dysfunction, leads to the disorders of lipid transporting system in the form of the resistant hyperlipidemia with the phenomena of dyslipidemia."
2.	Protamines (Protamine Sulfate)FDA Link 05/01/1975 - "Freed from the confusing effects of hyperheparinemia or protamine excess, the physician can diagnose and treat postoperative bleeding problems much more readily." 10/01/1976 - "Although hyperheparinemia, heparin rebound, and protamine excess have occasionally been incriminated as sources of hemorrhage during CPB, no well documented cases appear in the literature. "
3.	Cholinergic Agents (Cholinergics)IBA 05/28/1948 - "Similarity to Heparin of the Clotting Inhibitor in Acute Leucemia and the Significance of Hyperheparinemia in Estrapenic Cholinergic States."
4.	Testosterone (Sustanon)FDA Link 03/01/1952 - "[Influence of administration of testosterone and progesterone on induced hyperheparinemia]."
5.	ProgesteroneFDA LinkGeneric 03/01/1952 - "[Influence of administration of testosterone and progesterone on induced hyperheparinemia]."
6.	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 12/01/2014 - "The article describes known atherosclerosis predictors of endothelial origin, which are diagnostic criteria for identifying's early stages of atherosclerosis, and can prevent the development of this disease and are used to monitor the effectiveness of the therapy The authors analyzed the possibility of using heparin as an early marker of atherosclerosis, based on the fact that the inhibition of lipoprotein lipase activity due hyperheparinemia resulting from depletion of mast cells due to endothelial dysfunction, leads to the disorders of lipid transporting system in the form of the resistant hyperlipidemia with the phenomena of dyslipidemia."
7.	LipidsIBA 12/01/2014 - "The article describes known atherosclerosis predictors of endothelial origin, which are diagnostic criteria for identifying's early stages of atherosclerosis, and can prevent the development of this disease and are used to monitor the effectiveness of the therapy The authors analyzed the possibility of using heparin as an early marker of atherosclerosis, based on the fact that the inhibition of lipoprotein lipase activity due hyperheparinemia resulting from depletion of mast cells due to endothelial dysfunction, leads to the disorders of lipid transporting system in the form of the resistant hyperlipidemia with the phenomena of dyslipidemia."
8.	Fibrinogen (Factor I)FDA Link 06/01/1975 - "It appeared that at the period of the thrombus formation and during the first 5 minutes after its organization there occurred hypercoagulation changes in the blood and hypocoagulation of the plasma against the background of decrease in fibrinogen, hyperfibrinolysis, hyperheparinemia and thrombocytopenia. "

Therapies and Procedures

1.

Therapeutics 12/01/2014 - "The article describes known atherosclerosis predictors of endothelial origin, which are diagnostic criteria for identifying's early stages of atherosclerosis, and can prevent the development of this disease and are used to monitor the effectiveness of the therapy The authors analyzed the possibility of using heparin as an early marker of atherosclerosis, based on the fact that the inhibition of lipoprotein lipase activity due hyperheparinemia resulting from depletion of mast cells due to endothelial dysfunction, leads to the disorders of lipid transporting system in the form of the resistant hyperlipidemia with the phenomena of dyslipidemia."