Complementation Group F Xeroderma Pigmentosum

Also Known As:

Xeroderma Pigmentosum, Complementation Group F; XP, Group F; XP6; Xeroderma Pigmentosum Vi

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Precancerous Conditions: 304
  - Xeroderma Pigmentosum: 1866
    - Complementation Group F Xeroderma Pigmentosum: 11
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Skin Abnormalities: 159
    - Xeroderma Pigmentosum: 1866
      - Complementation Group F Xeroderma Pigmentosum: 11
- Inborn Genetic Diseases: 11939
  - Genetic Skin Diseases: 47
    - Xeroderma Pigmentosum: 1866
      - Complementation Group F Xeroderma Pigmentosum: 11
Skin and Connective Tissue Diseases
- Skin Diseases: 13127
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - DNA Repair-Deficiency Disorders: 538
    - Xeroderma Pigmentosum: 1866
      - Complementation Group F Xeroderma Pigmentosum: 11

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinogenesis
3.	Colorectal Neoplasms (Colorectal Cancer)
4.	Xeroderma Pigmentosum (Kaposi's Disease)

Experts

1.	Aung, Hsu Mon: 1 article (02/2021)
2.	Duangkaew, Marisa: 1 article (02/2021)
3.	Huangteerakul, Chananya: 1 article (02/2021)
4.	Ingkaninan, Kornkanok: 1 article (02/2021)
5.	Jensen, Amornrat Naranuntarat: 1 article (02/2021)
6.	Jensen, Laran T: 1 article (02/2021)
7.	Sukrong, Suchada: 1 article (02/2021)
8.	Thosapornvichai, Thitipa: 1 article (02/2021)
9.	Deng, Xiao-Dong: 1 article (07/2017)
10.	Gao, Qin: 1 article (07/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Complementation Group F Xeroderma Pigmentosum:

1.	EndonucleasesIBA 02/01/2008 - "Here we discuss recent additions to the current model and argue that the endonuclease xeroderma pigmentosum complementation group F-excision repair cross-complementing rodent repair deficiency complementation group 1 (XPF-ERCC1) has been heretofore misplaced. " 07/01/2002 - "The expression of xeroderma pigmentosum complementation group F (XPF), an endonuclease involved in NER, was upregulated in KCP-4 cells. " 02/24/2021 - "Colorectal cancer is a common cancer worldwide and reduced expression of the DNA repair endonuclease XPF (xeroderma pigmentosum complementation group F) is associated with colorectal cancer. " 10/05/2004 - "The xeroderma pigmentosum complementation group F (XPF) protein is a structure-specific endonuclease in a complex with ERCC1 and is essential for nucleotide excision repair (NER). " 07/01/2003 - "ERCC1 is a single-stranded DNA endonuclease that forms a tight heterodimer with xeroderma pigmentosum complementation group F. "
2.	Proteins (Proteins, Gene)FDA Link 10/01/2014 - "Because protein-protein interactions are essential for NER activity, we transfected human cancer cell lines (A549 and HCT116) with plasmids coding the amino acid sequences corresponding to the interacting domains between excision repair cross-complementation group 1 (ERCC1) and xeroderma pigmentosum, complementation group A (XPA), as well as ERCC1 and xeroderma pigmentosum, complementation group F (XPF), all NER proteins. " 10/05/2004 - "The xeroderma pigmentosum complementation group F (XPF) protein is a structure-specific endonuclease in a complex with ERCC1 and is essential for nucleotide excision repair (NER). " 01/15/2001 - "We have made a replication-defective adenovirus, AdCMV-FlagXPA(59-114), that expresses a truncated form of XPA encompassing amino acids 59-114 sufficient for binding to the excision repair cross-complementing protein 1 (ERCC1)/xeroderma pigmentosum complementation group F (XPF) nuclease essential for making an incision 5' of the damage. "
3.	EnzymesIBA 07/01/2017 - "Excision repair cross-complementation group1 (ERCC1) and Xeroderma pigmentosum complementation group F (XPF) were rate-limiting enzyme in nucleotide excision repair (NER) which was known as the most important DNA damage repair system. " 05/01/2012 - "Mammalian excision repair cross-complementing 1 (ERCC1) and ERCC4 (a.k.a xeroderma pigmentosum complementation group F) are nucleotide excision repair enzymes, which excise the 5' end of damaged DNA. "
4.	DNA (Deoxyribonucleic Acid)IBA 05/01/2012 - "Mammalian excision repair cross-complementing 1 (ERCC1) and ERCC4 (a.k.a xeroderma pigmentosum complementation group F) are nucleotide excision repair enzymes, which excise the 5' end of damaged DNA. " 06/01/2009 - "Slx4 interacts physically not only with Slx1, but also with Rad1-Rad10 [XPF (xeroderma pigmentosum complementation group F)-ERCC1 (excision repair cross-complementing 1) in humans], another structure-specific endonuclease that participates in the repair of UV-induced DNA damage and in a subpathway of recombinational DNA DSB (double-strand break) repair. "
5.	Nonsense Codon (Nonsense Mutation)IBA 03/10/2014 - "A nonsense mutation in the Xeroderma pigmentosum complementation group F (XPF) gene is associated with gastric carcinogenesis."
6.	Single-Stranded DNA (DNA, Single Stranded)IBA 07/01/2003 - "ERCC1 is a single-stranded DNA endonuclease that forms a tight heterodimer with xeroderma pigmentosum complementation group F. "
7.	Amino Acids FDA Link 01/15/2001 - "We have made a replication-defective adenovirus, AdCMV-FlagXPA(59-114), that expresses a truncated form of XPA encompassing amino acids 59-114 sufficient for binding to the excision repair cross-complementing protein 1 (ERCC1)/xeroderma pigmentosum complementation group F (XPF) nuclease essential for making an incision 5' of the damage. "
8.	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 06/01/2009 - "Slx4 interacts physically not only with Slx1, but also with Rad1-Rad10 [XPF (xeroderma pigmentosum complementation group F)-ERCC1 (excision repair cross-complementing 1) in humans], another structure-specific endonuclease that participates in the repair of UV-induced DNA damage and in a subpathway of recombinational DNA DSB (double-strand break) repair. "