Pili Torti

A condition in which the hair shafts are flattened and rotated along their long axis, resulting in fragility and breakage at short length which often resolves by adolescence. The nails and teeth may also be affected. OMIM: 261900

Also Known As:

Networked: 19 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Delayed Puberty
2.	Intellectual Disability (Idiocy)
3.	Menkes Kinky Hair Syndrome (Menkes Disease)
4.	Sensorineural Hearing Loss
5.	Diverticulum

Experts

1.	de Almeida, Hiram Larangeira: 2 articles (05/2020 - 11/2019)
2.	Chogale, Ritesh: 1 article (04/2021)
3.	Kaushik, Vaibhav: 1 article (04/2021)
4.	Mhaskar, Sudhakar: 1 article (04/2021)
5.	Leng, Xueqi: 1 article (01/2021)
6.	Li, Yaowang: 1 article (01/2021)
7.	Liu, Jiayu: 1 article (01/2021)
8.	Liu, Zunfeng: 1 article (01/2021)
9.	Sun, Jinkun: 1 article (01/2021)
10.	Xiao, Yicheng: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pili Torti:

1.	CopperIBA 05/01/2013 - "Their diagnosis was based on the characteristic morphological features, microscopic evidence of pili torti and low copper and ceruloplasmin levels. " 10/01/2007 - "The diagnosis, suggested by the clinical features, was rapidly supported by the microscopic examination of the hairs, showing pili torti, and the demonstration of severely decreased levels of plasma copper and ceruloplasmin. " 01/01/1992 - "We report a male infant with Menkes' disease who showed, at the age of 3 months, slow growth, hair abnormalities such as pili torti and white hair, and low levels of serum copper and ceruloplasmin. "
2.	Ceruloplasmin (Ferroxidase)IBA 05/01/2013 - "Their diagnosis was based on the characteristic morphological features, microscopic evidence of pili torti and low copper and ceruloplasmin levels. " 10/01/2007 - "The diagnosis, suggested by the clinical features, was rapidly supported by the microscopic examination of the hairs, showing pili torti, and the demonstration of severely decreased levels of plasma copper and ceruloplasmin. " 01/01/1992 - "We report a male infant with Menkes' disease who showed, at the age of 3 months, slow growth, hair abnormalities such as pili torti and white hair, and low levels of serum copper and ceruloplasmin. "
3.	Erlotinib Hydrochloride (CP 358,774)FDA Link 05/01/2020 - "At the ultrastructural level erlotinib-induced hair changes were already described as acquired pili torti et canaliculi. " 11/01/2019 - "Erlotinib-induced hair changes are pili torti et canaliculi." 11/01/2019 - "Scanning Electron Microscopy of Erlotinib-induced Hair Changes: Pili Torti et Canaliculi." 10/01/2016 - "Loose Anchoring of Anagen Hairs and Pili Torti due to Erlotinib." 10/01/2016 - "In this case report, we describe two patients with a new finding of loose anagen hairs and pili torti leading to nonscarring marginal and diffuse alopecia and discuss potential mechanisms underlying erlotinib-induced hair changes."
4.	DisulfidesIBA 01/01/2021 - "Here disulfide cross-linking was used to prepare novel tether-free hygroresponsive tensile and torsional fiber artificial muscles in twisted hair fibers. " 04/01/2017 - "Thus, the weakness of pili torti in tensile strength is thought to result from loose IF because of dysformation of disulfide bonds."
5.	Keratin-17 (Keratin 17)IBA 12/01/2003 - "Using intradermal injection of a chimeric RNA-DNA oligonucleotide (RDO) or a single-stranded oligonucleotide (ssODN) into murine skin, we attempted to make a dominant mutation (R94p) in the conserve alpha-helical domain of keratin 17 (K17), the same mutation found in pachyononychia congenichia type 2 (PC-2) patients with phenotypes ranging from twisted hair and multiple pilosebaceous cysts. "
6.	Insulin-Like Growth Factor Binding Protein 5IBA 02/01/2011 - "Overexpression of IGF-binding protein 5 (IGFBP-5) in the human hair xenografts obtained from straight- and curly-haired individuals was found to result in the decreased expression of several extracellular matrix proteins and disassembly of adhesional junctions, resulting in twisted hair shafts as well as an unusual deposition of hair cuticle that may be derived from the disturbance of normal proliferation and differentiation. "
7.	AcitretinFDA Link 09/12/2023 - "Progressive Kinking of the Hair and Pili Torti Secondary to Acitretin."
8.	Extracellular Matrix ProteinsIBA 02/01/2011 - "Overexpression of IGF-binding protein 5 (IGFBP-5) in the human hair xenografts obtained from straight- and curly-haired individuals was found to result in the decreased expression of several extracellular matrix proteins and disassembly of adhesional junctions, resulting in twisted hair shafts as well as an unusual deposition of hair cuticle that may be derived from the disturbance of normal proliferation and differentiation. "
9.	Isotretinoin (Accutane)FDA LinkGeneric 05/01/1985 - "Light microscopic examination revealed pili torti during the administration of isotretinoin. "
10.	Vitamin A (Retinol)FDA LinkGeneric 03/01/1996 - "We suggest a possible link between excess vitamin A and pili torti in patients with AN."

Therapies and Procedures

1.

Intradermal Injections 12/01/2003 - "Using intradermal injection of a chimeric RNA-DNA oligonucleotide (RDO) or a single-stranded oligonucleotide (ssODN) into murine skin, we attempted to make a dominant mutation (R94p) in the conserve alpha-helical domain of keratin 17 (K17), the same mutation found in pachyononychia congenichia type 2 (PC-2) patients with phenotypes ranging from twisted hair and multiple pilosebaceous cysts. "