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MC 2141

a SIRT1 antagonist; structure in first source

Also Known As:

MC-2141; MC2141

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - Quinazolinones: 124
        MC 2141: 1

Experts

1.	Altucci, Lucia: 1 article (09/2012)
2.	Botta, Giorgia: 1 article (09/2012)
3.	Carafa, Vincenzo: 1 article (09/2012)
4.	De Maria, Ruggero: 1 article (09/2012)
5.	Di Maro, Salvatore: 1 article (09/2012)
6.	Gallinari, Paola: 1 article (09/2012)
7.	Jung, Manfred: 1 article (09/2012)
8.	Mai, Antonello: 1 article (09/2012)
9.	Novellino, Ettore: 1 article (09/2012)
10.	Paolini, Chantal: 1 article (09/2012)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 09/27/2012 - "Some of the new benzodeazaoxaflavins (2a, 2b, and 2d) here reported as SIRT1/2 inhibitors were endowed with pro-apoptotic properties in human U937 leukemia cells and, most importantly, together with the prototype MC2141 (1) displayed antiproliferative effects in cancer stem cells from patients with colorectal carcinoma and glioblastoma multiforme, known to be highly tumorigenic, resistant to conventional cancer chemotherapy, and responsible, at least in part, for cancer relapse or recurrence."
2.	Neoplasms (Cancer) 09/27/2012 - "Some of the new benzodeazaoxaflavins (2a, 2b, and 2d) here reported as SIRT1/2 inhibitors were endowed with pro-apoptotic properties in human U937 leukemia cells and, most importantly, together with the prototype MC2141 (1) displayed antiproliferative effects in cancer stem cells from patients with colorectal carcinoma and glioblastoma multiforme, known to be highly tumorigenic, resistant to conventional cancer chemotherapy, and responsible, at least in part, for cancer relapse or recurrence."
3.	Leukemia 09/27/2012 - "Some of the new benzodeazaoxaflavins (2a, 2b, and 2d) here reported as SIRT1/2 inhibitors were endowed with pro-apoptotic properties in human U937 leukemia cells and, most importantly, together with the prototype MC2141 (1) displayed antiproliferative effects in cancer stem cells from patients with colorectal carcinoma and glioblastoma multiforme, known to be highly tumorigenic, resistant to conventional cancer chemotherapy, and responsible, at least in part, for cancer relapse or recurrence."
4.	Glioblastoma (Glioblastoma Multiforme) 09/27/2012 - "Some of the new benzodeazaoxaflavins (2a, 2b, and 2d) here reported as SIRT1/2 inhibitors were endowed with pro-apoptotic properties in human U937 leukemia cells and, most importantly, together with the prototype MC2141 (1) displayed antiproliferative effects in cancer stem cells from patients with colorectal carcinoma and glioblastoma multiforme, known to be highly tumorigenic, resistant to conventional cancer chemotherapy, and responsible, at least in part, for cancer relapse or recurrence."

Related Drugs and Biologics

1.	Sirtuin 1

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)