HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

3- (3- (pyridine- 3- yl)- 1,2,4- oxadiazol- 5- yl)benzonitrile

an alpha4beta2 nAChR agonist

Also Known As:

NS 9283; NS-9283; NS9283

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        3-(3-(pyridine-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile: 4
  - Pyridines: 88
    - 3-(3-(pyridine-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile: 4

Experts

1.	Blasio, Angelo: 1 article (01/2020)
2.	Cameron, Michael D: 1 article (01/2020)
3.	Chapman, Holly L: 1 article (01/2020)
4.	Doebelin, Christelle: 1 article (01/2020)
5.	Giovanetti, Simone M: 1 article (01/2020)
6.	Kamenecka, Theodore M: 1 article (01/2020)
7.	Kuryatov, Alexander: 1 article (01/2020)
8.	Liaw, Victor: 1 article (01/2020)
9.	Lin, Li: 1 article (01/2020)
10.	Lindstrom, Jon: 1 article (01/2020)

Related Diseases

1.	Pain (Aches) 06/06/2012 - "In the present study we applied the partial nAChR α4β2 LS and HS agonist NS3956 and the LS selective positive allosteric modulator NS9283 to investigate the role of α4β2 in Parkinson and pain models. " 10/15/2011 - "In monoiodo-acetate induced knee joint pain, co-administration of NS-9283 enhanced the potency of ABT-594 by 5-fold (ED(50)=1.0 vs. 4.6 nmol/kg). " 06/06/2012 - "In a rat formalin pain model NS3956 induced an analgesic response that was strongly potentiated by NS9283. "
2.	Neuralgia (Stump Neuralgia) 10/15/2011 - "Positive modulation of the neuronal nicotinic acetylcholine receptor (nAChR) α4β2 subtype by selective positive allosteric modulator NS-9283 has shown to potentiate the nAChR agonist ABT-594-induced anti-allodynic activity in preclinical neuropathic pain. " 10/15/2011 - "To determine whether this benefit can be extended beyond neuropathic pain, the present study examined the analgesic activity and adverse effect profile of co-administered NS-9283 and ABT-594 in a variety of preclinical models in rats. "
3.	Postoperative Pain 10/15/2011 - "In the paw skin incision model of post-operative pain, co-administration of NS-9283 similarly induced a 6-fold leftward shift of ABT-594 (ED(50)=26 vs. 153 nmol/kg). "
4.	Hyperalgesia 10/15/2011 - "In carrageenan-induced thermal hyperalgesia, co-administration of NS-9283 (3.5 μmol/kg, i.p.) induced a 6-fold leftward shift of the dose-response of ABT-594 (ED(50)=26 vs. 160 nmol/kg, i.p.). "
5.	Brain Diseases (Brain Disorder) 11/15/2013 - "In conclusion, our results indicate that a LS α4β2 nAChR PAM such as NS9283 may enhance the cholinergic modulation of glutamatergic neurotransmission in the cortex, thereby perhaps alleviating the attentional impairments common to a range of brain disorders. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	1-(5-chloropyridin-3-yl)-(1,4)diazepane
3.	5-(2-azetidinylmethoxy)-2-chloropyridine
4.	Cholinergic Agents (Cholinergics)
5.	Saccharin
6.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
7.	Formaldehyde (Formol)
8.	Carrageenan
9.	Ethanol (Ethyl Alcohol)
10.	Acetates (Acetic Acid Esters)