SAT05f

a synthetic single-stranded oligodeoxynucleotide with the sequence of human microsatellite DNA with capacity of alleviating lupus nephritis in the chronic graft versus host disease induced lupus-prone mice

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sun, Ran: 4 articles (08/2012 - 03/2010)
2.	Wang, Liying: 3 articles (11/2011 - 03/2010)
3.	Yu, Yongli: 3 articles (11/2011 - 03/2010)
4.	Zhang, Yongsheng: 3 articles (11/2011 - 03/2010)
5.	Zhao, Tiesuo: 2 articles (12/2016 - 09/2011)
6.	Wu, Xiuli: 2 articles (11/2011 - 03/2010)
7.	Ji, Yinghua: 1 article (12/2016)
8.	Jia, Huijie: 1 article (12/2016)
9.	Jia, Xiaolong: 1 article (12/2016)
10.	Li, Chen: 1 article (12/2016)

Related Diseases

1.	Shock 03/01/2010 - "The result showed that SAT05f could down-regulate TLR7/9-dependent IFN-alpha production in cultured human PBMC stimulated by inactivated Flu virus PR8 or HSV-1 or CpG ODN or imiquimod, protect d-GalN-treated mice from lethal shock induced by TLR9 agonist, not by TLR3/4 agonist. " 08/01/2012 - "SAT05f, an inhibitory ODN with CCT repeat sequence found in human microsatellite DNA, has been demonstrated to down-regulate TLR7/9-mediated innate immune response, protect mice from D-GalN/CpG ODN induced lethal shock, and reduce anti-ssDNA antibody level in the lupus-prone mice induced by chronic graft versus host disease (cGVHD). "
2.	Bronchiolitis Obliterans Syndrome 08/01/2012 - "SAT05f, an inhibitory ODN with CCT repeat sequence found in human microsatellite DNA, has been demonstrated to down-regulate TLR7/9-mediated innate immune response, protect mice from D-GalN/CpG ODN induced lethal shock, and reduce anti-ssDNA antibody level in the lupus-prone mice induced by chronic graft versus host disease (cGVHD). " 09/01/2011 - "A synthesized single-stranded oligodeoxynucleotide (ODN), designed as SAT05f with the sequence of human microsatellite DNA, has been studied for its capacity of alleviating the lupus nephritis in the chronic graft versus host disease (cGVHD) induced lupus-prone mice. "
3.	Weight Loss (Weight Reduction) 11/18/2011 - "Unexpectedly, SAT05f failed to lessen ALII in the mice, whereas MS19 significantly inhibited the weight loss and displayed dramatic effect on lessening the ALII by reducing consolidation, hemorrhage, intra-alveolar edema and neutrophils infiltration in lungs of the mice. "
4.	Lupus Nephritis 09/01/2011 - "These results indicated that SAT05f could be developed as a new therapeutic agent for the treatment of lupus nephritis by inhibiting TLR9 signaling pathways." 09/01/2011 - "In cGVHD model mice, both of continuous and discontinuous treatment with SAT05f was effective on reducing anti-ssDNA antibody production, decreasing renal IgG deposition and delaying the onset of lupus nephritis. " 09/01/2011 - "A synthesized single-stranded oligodeoxynucleotide (ODN), designed as SAT05f with the sequence of human microsatellite DNA, has been studied for its capacity of alleviating the lupus nephritis in the chronic graft versus host disease (cGVHD) induced lupus-prone mice. "
5.	Hemorrhage 11/18/2011 - "Unexpectedly, SAT05f failed to lessen ALII in the mice, whereas MS19 significantly inhibited the weight loss and displayed dramatic effect on lessening the ALII by reducing consolidation, hemorrhage, intra-alveolar edema and neutrophils infiltration in lungs of the mice. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	CPG-oligonucleotide
3.	Oligodeoxyribonucleotides
4.	Immunoglobulin G (IgG)
5.	Imiquimod (Aldara)
6.	nifuroxazide (Akabar)

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Therapeutics