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O2- (4- (3- pyridyl)- 4- oxobut- 1- yl)thymidine

formed by exposure to tobacco-specific nitrosamines; structure in first source

Also Known As:

O2-POB-dThd

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Thymidine: 4460
        O2-(4-(3-pyridyl)-4-oxobut-1-yl)thymidine: 1
  - Pyridines: 88
    - O2-(4-(3-pyridyl)-4-oxobut-1-yl)thymidine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Thymidine: 4460
      - O2-(4-(3-pyridyl)-4-oxobut-1-yl)thymidine: 1
  - Deoxyribonucleosides: 34
    - Thymidine: 4460
      - O2-(4-(3-pyridyl)-4-oxobut-1-yl)thymidine: 1

Experts

1.	Hecht, Stephen S: 1 article (05/2006)
2.	Lao, Yanbin: 1 article (05/2006)
3.	Sturla, Shana J: 1 article (05/2006)
4.	Villalta, Peter W: 1 article (05/2006)
5.	Wang, Mingyao: 1 article (05/2006)

Related Diseases

1.	Carcinogenesis 05/01/2006 - "The results of this study provide a sensitive HPLC-ESI-MS/MS method for comprehensive quantitation of four POB-DNA adducts, support an important role of O6-POB-dGuo in NNK lung tumorigenicity in rats, and suggest that O2-POB-dThd may be a useful tobacco-specific DNA biomarker for future tobacco carcinogenesis studies."

Related Drugs and Biologics

1.	DNA Adducts
2.	Biomarkers (Surrogate Marker)
3.	DNA (Deoxyribonucleic Acid)