IMMLG5521

10/01/2012 - "The study is to investigate the effect of compound IMMLG5521, a coumarin derivative, on lung inflammation induced by Sephadex in rats. "
10/01/2012 - "Anti-inflammatory effect of IMMLG5521, a coumarin derivative, on Sephadex-induced lung inflammation in rats."

10/01/2013 - "The compound IMMLG5521 can inhibit inflammation in vitro and in vivo."
10/01/2013 - "Taken together, the compound IMMLG5521 inhibited the release of inflammatory factors and mediators in vitro, decreased inflammation response in mice. "
10/01/2013 - "In vivo, we evaluated the effect of IMMLG5521 on acute and chronic inflammation models. "
07/01/2011 - "The results showed that IMMLG5521 (5, 10 and 20 mg/kg) exhibited anti-inflammatory effects, reducing pleural exudate formation, decreasing total number of inflammation cells and polymorphonuclear leukocytes infiltration, attenuating histological injury and reducing TNF-α, IL-1β, MIP-2 and IL-8 release. "
07/01/2011 - "Taken together, the present results suggested that IMMLG5521 inhibited acute inflammation in carrageenan-induced pleurisy model that could be, in part, related to a reduction of release of inflammatory factors, another part may be related to an inhibition of NF-кB activation."

10/01/2013 - "Our data showed that IMMLG5521 (6mg/kg, 12mg/kg) could inhibit xylene-induced ear swelling and cotton pellet-induced granuloma formation in mice. "
10/01/2012 - "However, pretreatment with IMMLG5521 (6.25 and 12.5 mg/kg) inhibited massive granulomas and infiltration of neutrophils and eosinophils, decreased TNF-α level in BALF and lung tissue, and down-regulated VCAM-1 and ICAM-1 expressions in the lung tissue. "

10/01/2012 - "In conclusion, compound IMMLG5521 may suppress the lung injury induced by Sephadex, at least in part, due to the prevention of the up-regulation of VCAM-1 and ICAM-1 expressions and TNF-α level."

07/01/2011 - "Taken together, the present results suggested that IMMLG5521 inhibited acute inflammation in carrageenan-induced pleurisy model that could be, in part, related to a reduction of release of inflammatory factors, another part may be related to an inhibition of NF-кB activation."
07/01/2011 - "To investigate the potential anti-inflammatory effect of compound IMMLG5521, a novel coumarin derivative, carrageenan-induced pleurisy model in rats was employed. "
07/01/2011 - "Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy in rats."