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PXS25 compound

mannose 6-phosphate analog that inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-beta1

Also Known As:

PXS25

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Sugar Phosphates: 20
  - Hexosephosphates: 2
    - Mannosephosphates
      - PXS25 compound: 2

Experts

1.	Wong, Muh Geot: 2 articles (01/2015 - 07/2011)
2.	Chen, Jason: 1 article (01/2015)
3.	Gross, Simon: 1 article (01/2015)
4.	Pollock, Carol: 1 article (01/2015)
5.	Saad, Sonia: 1 article (01/2015)
6.	Wong, May: 1 article (01/2015)
7.	Zhang, Jie: 1 article (01/2015)
8.	Chen, Xin-Ming: 1 article (07/2011)
9.	Panchapakesan, Usha: 1 article (07/2011)
10.	Pollock, Carol A: 1 article (07/2011)

Related Diseases

1.	Fibrosis (Cirrhosis) 07/01/2011 - "PXS25, a novel CI-MPR inhibitor, has antifibrotic properties in skin fibroblasts, but its role in renal fibrosis is unclear. " 01/01/2015 - "Our aim was to determine the effects of PXS64, a pro-drug of PXS25, in in vitro and in vivo models of renal fibrosis. " 07/01/2011 - "Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-beta1."
2.	Hyperglycemia 07/01/2011 - "Hyperglycemia induced fibronectin and collagen IV production (P < 0.05), as did hypoxia, but only hyperglycemia-induced increases in matrix proteins were suppressed by concurrent PXS25 exposure. "
3.	Hypoxia (Hypoxemia) 07/01/2011 - "PXS25 inhibits conversion of high glucose-induced release of active TGF-β(1), only in the absence of hypoxia." 07/01/2011 - "Hyperglycemia induced fibronectin and collagen IV production (P < 0.05), as did hypoxia, but only hyperglycemia-induced increases in matrix proteins were suppressed by concurrent PXS25 exposure. "

Related Drugs and Biologics

1.	Transforming Growth Factor beta1 (TGF beta 1)
2.	Proteins (Proteins, Gene)
3.	Prodrugs
4.	Mannose (D-Mannose)
5.	Glucose (Dextrose)
6.	Fibronectins (Fibronectin)
7.	Collagen
8.	Cations