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3- ((4- (2- styrylphenoxy)butanoyl)- 4- hydroxyprolyl)thiazolidine

inhibits prolyl oligopeptidase

Also Known As:

SUAM 14746; SUAM-14746; SUAM14746

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Cyclic Amino Acids: 3
    - Imino Acids: 11
      - Proline: 3391
        3-((4-(2-styrylphenoxy)butanoyl)-4-hydroxyprolyl)thiazolidine: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiazolidines: 105
      - 3-((4-(2-styrylphenoxy)butanoyl)-4-hydroxyprolyl)thiazolidine: 2

Experts

1.	Sakaguchi, Minoru: 2 articles (10/2021 - 09/2017)
2.	Tanaka, Satoshi: 2 articles (10/2021 - 09/2017)
3.	Bando, Mika: 1 article (10/2021)
4.	Ikeguchi, Shiori: 1 article (10/2021)
5.	Kanazawa, Miyuki: 1 article (10/2021)
6.	Kikyo, Fumi: 1 article (10/2021)
7.	Kondo, Rie: 1 article (10/2021)
8.	Mitsumori, Mika: 1 article (10/2021)
9.	Nishiuchi, Ryota: 1 article (10/2021)
10.	Shiokawa, Ai: 1 article (10/2021)

Related Diseases

1.	Neuroblastoma 10/01/2021 - "Previously, we reported that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a binding partner of prolyl oligopeptidase (POP) in neuroblastoma NB-1 cells and that the POP inhibitor, SUAM-14746, inhibits cytosine arabinoside (Ara-C)-induced nuclear translocation of GAPDH and protects against Ara-C cytotoxicity. "
2.	Breast Neoplasms (Breast Cancer) 09/01/2017 - "SUAM-14746 inhibited breast cancer cell growth in a cytostatic manner without inducing lethality, and POP-specific inhibitors may be an effective treatment against ER+ and ER- breast cancer." 09/01/2017 - "The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro."

Related Drugs and Biologics

1.	Prolyl Oligopeptidases
2.	Cytostatic Agents
3.	Oxidoreductases (Dehydrogenase)
4.	Glyceraldehyde 3-Phosphate (Glyceraldehyde 3 Phosphate)
5.	Cytarabine (Cytosar-U)