N- (bicyclo(2.2.1)hept- 2- yl)- 2- methyl- 5- (4- (trifluoromethyl)phenyl)- 4- pyrimidinamine

a GABA-B receptor agonist

Also Known As:

BHF 177; BHF-177; BHF177

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - Bridged Bicyclo Compounds
        Norbornanes: 4
        N-(bicyclo(2.2.1)hept-2-yl)-2-methyl-5-(4-(trifluoromethyl)phenyl)-4-pyrimidinamine: 5
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - Bridged Bicyclo Compounds
    - Norbornanes: 4
      - N-(bicyclo(2.2.1)hept-2-yl)-2-methyl-5-(4-(trifluoromethyl)phenyl)-4-pyrimidinamine: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - N-(bicyclo(2.2.1)hept-2-yl)-2-methyl-5-(4-(trifluoromethyl)phenyl)-4-pyrimidinamine: 5

Experts

1.	Finn, M G: 2 articles (01/2017 - 10/2015)
2.	Li, Xia: 2 articles (01/2017 - 10/2015)
3.	Markou, Athina: 2 articles (01/2017 - 10/2015)
4.	Cameron, Michael: 1 article (01/2017)
5.	Griffin, Patrick R: 1 article (01/2017)
6.	Kaczanowska, Kasia: 1 article (01/2017)
7.	McDonald, Patricia: 1 article (01/2017)
8.	Sturchler, Emmanuel: 1 article (01/2017)
9.	de Lourdes Ladino, Maria: 1 article (01/2017)
10.	Kaczanowska, Katarzyna: 1 article (10/2015)

Related Diseases

1.	Gastroesophageal Reflux (GERD) 01/01/2010 - "This chapter presents new clinical applications of the prototypic GABA(B) receptor agonist baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine, morphine, and heroin, a novel baclofen prodrug Arbaclofen placarbil, the GABA(B) receptor agonist AZD3355 (Lesogabaran) currently in Phase 2 clinical trials for the treatment of gastroesophageal reflux disease, and four positive allosteric modulators of GABA(B) receptors (CGP7930, GS39783, NVP-BHF177, and BHFF), which have less propensity for the development of tolerance due to receptor desensitization than classical GABA(B) receptor agonists. "
2.	Drug Resistant Epilepsy 11/01/2022 - "Effects of GABAB receptor positive allosteric modulator BHF177 and IRS-1 on apoptosis of hippocampal neurons in rats with refractory epilepsy via the PI3K/Akt pathway." 11/01/2022 - "The present study was conducted to determine the effects of the γ-aminobutyric acid B (GABAB ) receptor positive allosteric modulator BHF177 on refractory epilepsy (RE). "
3.	Tobacco Use Disorder (Nicotine Dependence) 01/01/2017 - "The positive allosteric modulators (PAMs) of GABABR GS39783 and BHF177 enhance GABA-stimulated [35S]GTP γS-binding, and have shown efficacy in a rodent nicotine self-administration procedure reflecting aspects of nicotine dependence. "
4.	Neuralgia (Stump Neuralgia) 01/01/2022 - "BHF177 Suppresses Diabetic Neuropathic Pain by Blocking PKC/CaMKII/ERK1/2/CREB Signaling Pathway through Activating GABAB Receptor."
5.	Mental Disorders (Mental Disorder) 10/01/2015 - "Thus, BHF177 or other GABAB receptor PAMs may be promising compounds for alleviating increased anxiety seen in various psychiatric disorders with a superior side-effect profile compared to GABAB receptor agonists. "

Related Drugs and Biologics

1.	Nicotine
2.	N,N'- dicyclopentyl- 2- methylsulfanyl- 5- nitro- pyrimidine- 4,6- diamine
3.	GABA-B Receptor Agonists
4.	GABA-B Receptors
5.	Prodrugs
6.	Morphine (MS Contin)
7.	Heroin (Diamorphine)
8.	Cocaine (Cocaine HCl)
9.	Baclofen
10.	Aminobutyrates (Aminobutyric Acid)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)