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protuboxepin A

cytotoxic from the marine-derived fungus Aspergillus sp. SF-5044; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ethers: 242
  - Cyclic Ethers: 12
    - Oxepins: 16
      - protuboxepin A: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxepins: 16
    - protuboxepin A: 1

Experts

1.	Ahn, Jong Seog: 1 article (06/2012)
2.	Asami, Yukihiro: 1 article (06/2012)
3.	He, Long: 1 article (06/2012)
4.	Jang, Jae-Hyuk: 1 article (06/2012)
5.	Kim, Bo Yeon: 1 article (06/2012)
6.	Kim, Jong Won: 1 article (06/2012)
7.	Moon, Dong Oh: 1 article (06/2012)
8.	Muroi, Makoto: 1 article (06/2012)
9.	Oh, Hyuncheol: 1 article (06/2012)
10.	Osada, Hiroyuki: 1 article (06/2012)

Related Diseases

1.

Neoplasms (Cancer)

06/15/2012 - "In this study we elucidated the mechanism by which protuboxepin A induces cancer cell growth inhibition. "
06/15/2012 - "These results indicate that protuboxepin A has a potential of being a new and effective anti-cancer drug."
06/15/2012 - "Here we report that protuboxepin A induced round-up morphology, M phase arrest, and an increase in the subG(1) population in tumor cells in a dose dependent manner. "
06/15/2012 - "Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells."
06/15/2012 - "Previously we reported the identification of a new oxepin-containing diketopiperazine-type marine fungal metabolite, named protuboxepin A which showed antiproliferative activity in several cancer cell lines. "

Related Drugs and Biologics

1.	Diketopiperazines
2.	Oxepins (Oxepin)