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(5- (4- amino- 6- bromo- 5- carbamoyl- 1H- pyrrolo(2,3- d)pyrimidin- 1- yl)- 3,4- dihydroxytetrahydrofuran- 2- yl)methyl isobutyrate

ibutocydine is the (2S,3S,4S,5S)-isomer; prodrug of BMK-Y101; antineoplastic agent that inhibits both Cdk7 and Cdk9; structure in first source

Also Known As:

ibulocydine

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - (5-(4-amino-6-bromo-5-carbamoyl-1H-pyrrolo(2,3-d)pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - (5-(4-amino-6-bromo-5-carbamoyl-1H-pyrrolo(2,3-d)pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate: 3

Experts

1.	Kim, B Moon: 3 articles (01/2017 - 06/2011)
2.	Cho, Dong-Hyung: 2 articles (01/2017 - 08/2014)
3.	Choi, Eun Kyung: 2 articles (01/2017 - 08/2014)
4.	Hwang, Jung Jin: 2 articles (01/2017 - 08/2014)
5.	Jeong, Seong-Yun: 2 articles (01/2017 - 08/2014)
6.	Ju, Eun Jin: 2 articles (01/2017 - 08/2014)
7.	Lee, Jung Shin: 2 articles (01/2017 - 08/2014)
8.	Park, Seok Soon: 2 articles (01/2017 - 08/2014)
9.	Shin, Seol Hwa: 2 articles (01/2017 - 08/2014)
10.	Song, Si Yeol: 2 articles (01/2017 - 08/2014)

Related Diseases

1.	Neoplasms (Cancer) 06/03/2011 - "These results suggest that ibulocydine is a strong candidate anti-cancer drug for the treatment of HCC." 08/01/2014 - "Ibulocydine sensitizes human cancers to radiotherapy by induction of mitochondria-mediated apoptosis." 08/01/2014 - "Ibulocydine (IB), a novel prodrug of CDK inhibitor, has been reported to have anti-cancer effect in human hepatoma cells. " 06/03/2011 - "In this study, we showed that ibulocydine (an isobutyrate prodrug of the specific Cdk inhibitor, BMK-Y101) is a candidate anti-cancer drug for HCC. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2017 - "Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage." 06/03/2011 - "Ibulocydine is a novel prodrug Cdk inhibitor that effectively induces apoptosis in hepatocellular carcinoma cells." 08/01/2014 - "Ibulocydine (IB), a novel prodrug of CDK inhibitor, has been reported to have anti-cancer effect in human hepatoma cells. "

Related Drugs and Biologics

1.	Prodrugs
2.	4- amino- 6- bromo- 1- (3,4- dihydroxy- 5- (hydroxymethyl)tetrahydrofuran- 2- yl)- 1H- pyrrolo(2,3- d)pyrimidine- 5- carboxamide
3.	Calpain

Related Therapies and Procedures

1.	Radiotherapy