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ezutromid

a utrophin upregulator; structure in first source

Also Known As:

5-(ethylsulfonyl)-2-(naphthalen-2-yl)benzo(d)oxazole; 5-ethylsulfonyl-NBO

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxazoles: 68
      - ezutromid: 3
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        ezutromid: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - ezutromid: 3

Experts

1.	Davies, Kay E: 3 articles (12/2020 - 10/2019)
2.	Harriman, Shawn: 3 articles (12/2020 - 10/2019)
3.	Chatzopoulou, Maria: 2 articles (12/2020 - 01/2020)
4.	Davies, Stephen G: 2 articles (12/2020 - 01/2020)
5.	Elsey, David J: 2 articles (12/2020 - 01/2020)
6.	Emer, Enrico: 2 articles (12/2020 - 01/2020)
7.	Fletcher, Ai M: 2 articles (12/2020 - 01/2020)
8.	Robinson, Neil: 2 articles (12/2020 - 01/2020)
9.	Rowley, Jessica A: 2 articles (12/2020 - 01/2020)
10.	Russell, Angela J: 2 articles (12/2020 - 01/2020)

Related Diseases

1.

Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)

10/01/2019 - "A Phase 1b Trial to Assess the Pharmacokinetics of Ezutromid in Pediatric Duchenne Muscular Dystrophy Patients on a Balanced Diet."
01/10/2020 - "Following on from ezutromid, the first-in-class benzoxazole utrophin modulator that progressed to Phase 2 clinical trials for the treatment of Duchenne muscular dystrophy, a new chemotype was designed to optimise its physicochemical and ADME profile. "
12/01/2020 - "5-(Ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole (ezutromid, 1) is a first-in-class utrophin modulator that has been evaluated in a phase 2 clinical study for the treatment of Duchenne muscular dystrophy (DMD). "
10/01/2019 - "Ezutromid (SMT C1100) is a small-molecule utrophin modulator that was developed to treat Duchenne muscular dystrophy (DMD). "

Related Drugs and Biologics

1.	Utrophin
2.	Benzoxazoles
3.	Oxazoles
4.	SMT C1100