Carthamus yellow

anti-inflammatory main constituent of safflower, composed of safflomin A and safflomin B; structure of both in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Melanoma (Melanoma, Malignant) 03/01/2013 - "Here, our results demonstrate that carthamus yellow reduced the activity of mushroom tyrosinase in a dose-dependent manner with a half maximal inhibitory concentration (IC(50)) value of approximately 1.01 ± 0.03 mg/mL. A kinetic study of carthamus yellow on tyrosinase exhibited a mode of competitive inhibition with a Ki of 0.607 mg/mL. Moreover, cell viability analysis indicated that carthamus yellow used at concentrations of 1.0-4.0 mg/mL had no cytotoxicity in B16F10 melanoma cells. " 03/01/2013 - "Melanin content analysis showed that melanin production in B16F10 melanoma cells treated with 4 mg/mL carthamus yellow can decrease to 82.3 ± 0.4% of the levels of melanin production of untreated cells. "
2.	Inflammation (Inflammations) 01/30/2011 - "Protective effect of dried safflower petal aqueous extract and its main constituent, carthamus yellow, against lipopolysaccharide-induced inflammation in RAW264.7 macrophages."

1.	Monophenol Monooxygenase (Tyrosinase)
2.	Melanins (Melanin)
3.	Lipopolysaccharides