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PF 04886847

structure in first source

Also Known As:

PF-04886847; PF04886847

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kolte, D: 2 articles (06/2012 - 04/2011)
2.	Shariat-Madar, Z: 2 articles (06/2012 - 04/2011)
3.	Wang, J: 2 articles (06/2012 - 04/2011)
4.	Bryant, J W: 1 article (06/2012)
5.	Gibson, G W: 1 article (06/2012)
6.	Akbari, P: 1 article (04/2011)
7.	Bryant, Jw: 1 article (04/2011)
8.	Gibson, Gw: 1 article (04/2011)
9.	Holsworth, D: 1 article (04/2011)

Related Diseases

1.	Sepsis (Septicemia) 06/01/2012 - "PF-04886847 significantly reduced the elevated plasma 6-keto PGF1α levels in LPS treated rats, suggesting that PF-04886847 could be useful in preventing hypotensive shock during sepsis. " 06/01/2012 - "In the rat model of lipopolysaccharide (LPS) -induced sepsis used in this study, pretreatment of rats with PF-04886847 (1 mg/kg) prior to LPS (10 mg/kg) prevented endotoxin-induced increase in granulocyte count in the systemic circulation. " 06/01/2012 - "PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsis."
2.	Thrombosis (Thrombus) 06/01/2012 - "In a rabbit balloon injury model designed to mimic clinical conditions of acute thrombotic events, PF-04886847 reduced thrombus mass dose-dependently. "
3.	Shock 06/01/2012 - "PF-04886847 significantly reduced the elevated plasma 6-keto PGF1α levels in LPS treated rats, suggesting that PF-04886847 could be useful in preventing hypotensive shock during sepsis. "
4.	Inflammation (Inflammations) 04/01/2011 - "In addition, the effect of PF-04886847 on BK-induced relaxation of the rat aortic ring was determined in a model of lipopolysaccharide-induced tissue inflammation. "
5.	Hemorrhage 06/01/2012 - "Since prekallikrein (the zymogen form of plasma kallikrein) deficient patients have prolonged activated partial thromboplastin time (aPTT) without having any bleeding disorder, the anti-thrombotic property and mechanism of action of PF-04886847 was assessed. "

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Endotoxins
3.	Plasma Kallikrein
4.	Prekallikrein
5.	Enzyme Precursors (Zymogens)
6.	Dacarbazine (DIC)