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2- (4- aminophenyl)- 6- (2- fluoroethoxy)quinoline

structure in first source

Also Known As:

(18)F-THK523; 18F-THK523; THK523

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - 2-(4-aminophenyl)-6-(2-fluoroethoxy)quinoline: 4
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 2-(4-aminophenyl)-6-(2-fluoroethoxy)quinoline: 4

Experts

1.	Fodero-Tavoletti, Michelle T: 3 articles (05/2014 - 04/2011)
2.	Furumoto, Shozo: 3 articles (05/2014 - 04/2011)
3.	Kudo, Yukitsuka: 3 articles (05/2014 - 04/2011)
4.	Masters, Colin L: 3 articles (05/2014 - 04/2011)
5.	Mulligan, Rachel S: 3 articles (05/2014 - 04/2011)
6.	Okamura, Nobuyuki: 3 articles (05/2014 - 04/2011)
7.	Rowe, Christopher C: 3 articles (05/2014 - 04/2011)
8.	Villemagne, Victor L: 3 articles (05/2014 - 04/2011)
9.	Yanai, Kazuhiko: 3 articles (05/2014 - 04/2011)
10.	Harada, Ryuichi: 2 articles (05/2014 - 01/2014)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2014 - "The introduction of tau imaging agents such as (18)F-THK523 offers new hope for the in vivo assessment of tau deposition in tauopathies such as Alzheimer's disease (AD), where preliminary (18)F-THK523-PET studies have demonstrated significantly higher cortical retention of (18)F-THK523 in AD compared to age-matched healthy individuals. " 01/01/2014 - "Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non-Alzheimer's disease tauopathies." 04/01/2011 - "Autoradiographic and histofluorescence analysis of human hippocampal serial sections with Alzheimer's disease exhibited positive THK523 binding that co-localized with immunoreactive tau pathology, but failed to highlight β-amyloid plaques. " 04/01/2011 - "18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease."
2.	Tauopathies 01/01/2014 - "Although THK523 labelled tau-containing lesions such as neurofibrillary tangles and neuropil threads in the hippocampus and frontal regions of AD brains, it failed to label tau-containing lesions in non-AD tauopathies. " 01/01/2014 - "The introduction of tau imaging agents such as (18)F-THK523 offers new hope for the in vivo assessment of tau deposition in tauopathies such as Alzheimer's disease (AD), where preliminary (18)F-THK523-PET studies have demonstrated significantly higher cortical retention of (18)F-THK523 in AD compared to age-matched healthy individuals. " 01/01/2014 - "Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non-Alzheimer's disease tauopathies." 01/01/2014 - "The results of this study suggest that (18)F-THK523 selectively binds to paired helical filament tau in AD brains but does not bind to tau lesions in non-AD tauopathies, or to α-synuclein in PD brains."
3.	Parkinson Disease (Parkinson's Disease) 01/01/2014 - "To further investigate the ability of THK523 to recognize tau lesions, we undertook immunohistochemical and fluorescence studies in serial brain sections taken from individuals with AD (n = 3), CBD (n = 2), PSP (n = 1), PiD (n = 2) and Parkinson's disease (PD; n = 2). "
4.	Amyloid Plaque 04/01/2011 - "Autoradiographic and histofluorescence analysis of human hippocampal serial sections with Alzheimer's disease exhibited positive THK523 binding that co-localized with immunoreactive tau pathology, but failed to highlight β-amyloid plaques. "
5.	Frontotemporal Dementia (Semantic Dementia) 05/01/2014 - "Ten healthy elderly controls, three semantic dementia (SD) and ten AD patients underwent neuropsychological examination, MRI as well as (18)F-THK523 and (11)C-Pittsburgh compound B (PIB) positron emission tomography (PET) scans. "

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