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5-hydroxysaxagliptin

pharmacologically active metabolite of saxagliptin

Also Known As:

5-hydroxy saxagliptin

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Adamantane: 182
        5-hydroxysaxagliptin: 2
    - Bridged-Ring Compounds: 1
      - Adamantane: 182
        5-hydroxysaxagliptin: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - 5-hydroxysaxagliptin: 2

Experts

1.	Boulton, David W: 2 articles (01/2022 - 04/2011)
2.	Butrovich, Morgan A: 1 article (01/2022)
3.	Nolin, Thomas D: 1 article (01/2022)
4.	Sharma, Pradeep: 1 article (01/2022)
5.	Tang, Weifeng: 1 article (01/2022)
6.	Castaneda, Lorna: 1 article (04/2011)
7.	Frevert, Ernst U: 1 article (04/2011)
8.	Kornhauser, David M: 1 article (04/2011)
9.	Li, Li: 1 article (04/2011)
10.	Patel, Chirag G: 1 article (04/2011)

Related Diseases

1.	Chronic Renal Insufficiency 01/01/2022 - "We characterized the impact of chronic kidney disease (CKD) on the cytochrome P450 (CYP) 3A4-mediated metabolism of saxagliptin to its metabolite, 5-hydroxysaxagliptin, using a physiologically based pharmacokinetic (PBPK) model. "
2.	Chronic Kidney Failure (Chronic Renal Failure) 04/01/2011 - "Therefore, the pharmacokinetics and tolerability of saxagliptin and its pharmacologically active metabolite, 5-hydroxy saxagliptin, in nondiabetic subjects with mild, moderate or severe renal or hepatic impairment, or end-stage renal disease (ESRD) were compared with saxagliptin and metabolite pharmacokinetics and tolerability in healthy adult subjects. "

Related Drugs and Biologics

1.	saxagliptin
2.	Cytochrome P-450 Enzyme System (Cytochrome P450)