2F5 monoclonal antibody

broadly neutralizing monoclonal antibody targeting the membrane proximal external region (MPER) of HIV-1 gp41; a promising target for vaccine development

Also Known As:

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cano-Sánchez, Patricia: 1 article (01/2016)
2.	Garay-Canales, Claudia: 1 article (01/2016)
3.	Lara-González, Samuel: 1 article (01/2016)
4.	Mares-Mejía, Israel: 1 article (01/2016)
5.	Martínez-Caballero, Siseth: 1 article (01/2016)
6.	Ortega, Enrique: 1 article (01/2016)
7.	Rodríguez-Romero, Adela: 1 article (01/2016)
8.	Torres-Larios, Alfredo: 1 article (01/2016)
9.	Alam, S Munir: 1 article (01/2008)
10.	Gorny, Miroslaw K: 1 article (01/2008)

Related Diseases

1.	Infections 09/01/1996 - "These results indicate that the region (amino acids 641-685) of HIV-1 gp41 is the second site by which gp41 interacts with human cells, and suggest that the neutralization of HIV-1 infection by mAb 2F5 may be based on the fact that it blocks interaction of gp41 on virions with the gp41 binding molecules on human cells." 06/01/1995 - "The segment of gp41 encompassing residues ELDKWA has so far not been directly implicated in initiation of infection by HIV-1, suggesting that MAb 2F5 might affect other sites on HIV-1 envelope glycoproteins playing a role in virus entry into target cells. " 01/01/2008 - "To probe MPER anti-gp41 antibodies that are produced in HIV-1 infection, we have made two novel murine MAbs, 5A9 and 13H11, against HIV-1 gp41 envelope that partially cross-blocked 2F5 MAb binding to Env but did not neutralize HIV-1 primary isolates or bind host lipids. "
2.	HIV Infections (HIV Infection) 09/01/1996 - "We demonstrated by flow cytometry that mAb 2F5 could block gp41-binding to human cell lines H9 (T cells), Raji and U937, but the control mAb 4E10 that recognizes another region of gp41 (amino acids 686-728) and can not inhibit HIV infection, did not block this binding. "
3.	Leukemia 01/01/2016 - "We produced a novel monoclonal murine IgE (mAb 2F5), specific for rHev b 8, which was useful to provide evidence that profilin dimerization considerably increases the IgE-mediated degranulation in rat basophilic leukemia cells."

Related Drugs and Biologics

1.	Profilins (Profilin)
2.	Lipids
3.	Immunoglobulin E (IgE)
4.	Glycoproteins (Glycoprotein)
5.	Antibodies
6.	Amino Acids
7.	4E10 monoclonal antibody