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phenanthrene tetraol

minor enantiomers in human urine; structure in first source
Also Known As:
phe-(1R,2S,3R,4S)-tetraol; phe-(1S,2R,3S,4R)-tetraol
Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Hecht, Stephen S: 2 articles (01/2016 - 05/2014)
2. Carmella, Steven G: 1 article (01/2016)
3. Haiman, Christopher A: 1 article (01/2016)
4. Le Marchand, Loic: 1 article (01/2016)
5. Olvera, Natalie: 1 article (01/2016)
6. Paiano, Viviana: 1 article (01/2016)
7. Park, Sungshim L: 1 article (01/2016)
8. Patel, Yesha M: 1 article (01/2016)
9. Stram, Daniel O: 1 article (01/2016)
10. Gao, Yu-Tang: 1 article (05/2014)

Related Diseases

1. Lung Neoplasms (Lung Cancer)
01/01/2016 - "Consistent with their lung cancer risk and our previous studies of several other carcinogens and toxicants of cigarette smoke, African Americans had significantly (p<0.0001) higher median levels of the two phenanthrene metabolites 3-hydroxyphenanthrene (3-PheOH, 0.931 pmol/ml) and phenanthrene tetraol (PheT, 1.13 pmol/ml) than Whites (3-PheOH, 0.697 pmol/ml; PheT, 0.853 pmol/ml) while Japanese-Americans had significantly (p = 0.002) lower levels of 3-PheOH (0.621 pmol/ml) than Whites. "
05/15/2014 - "The prospectively collected urine samples from lung cancer cases and matching controls selected for this study, all current smokers, have been previously analyzed for total NNAL, cotinine (a biomarker of nicotine intake) and phenanthrene tetraol (PheT) (a biomarker of exposure to polycyclic aromatic hydrocarbons). "
01/01/2023 - "Using data from a subcohort of 2,309 current smokers at the time of urine collection from the Multiethnic Cohort Study, we prospectively evaluated the association of ten urinary biomarkers of smoking-related toxicants [total nicotine equivalents (TNE), a ratio of total trans-3'-hydroxycotinine (3-HCOT)/cotinine (a phenotypic measure of CYP2A6 enzymatic activity), 4-(methylnitrosamino)-1-3-(pyridyl)-1-butanol (NNAL), S-phenylmercapturic acid (SPMA), 3-hydroxypropyl mercapturic acid (3-HPMA), phenanthrene tetraol (PheT), 3-hydroxyphenanthrene (PheOH), the ratio of PheT/PheOH, cadmium (Cd), and (Z)-7-(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenyl]hept-5-enoic acid (8-iso-PGF2α)] with lung cancer risk (n = 140 incident lung cancer cases over an average of 13.4 years of follow-up). "

Related Drugs and Biologics

1. Biomarkers (Surrogate Marker)
2. Nicotine
3. Cotinine
4. Smoke
5. Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)
6. Carcinogens
7. phenanthrene
8. Cadmium
9. Acids
10. Acetylcysteine (Siran)