5- (6- hydroxy- 4- oxo- 2- thioxo- 1,2,3,4- tetrahydroxy- 5- pyrimidinyl)- 2,4- pentadienylidene- 2- thioxodihydro- 4,6(1H,5H)- pyrimidinedione

01/01/2012 - "In summary, our results support the use of the NIRF probe THK-265 for the diagnosis and direct visualization of amyloid deposits and open the possibility for efficient, pre-symptomatic monitoring of Aβ deposition in the aging brain."
01/01/2011 - "Furthermore, the fluorescence intensity of THK-265 correlated with amyloid plaque burden in the brains of AβPP transgenic mice. "
01/01/2011 - "THK-265 clearly stained amyloid plaques in AD neocortical brain sections and showed a moderate log p value (1.8). "
01/01/2011 - "We developed THK-265 as a candidate near-infrared fluorescence (NIRF) probe for the in vivo detection of amyloid deposits in the brain. "
01/01/2011 - "In vivo detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe THK-265."

01/01/2012 - "Ex vivo microscopy of i) THK-265-labeling of plaques in paraffin-embedded tissue and ii) cerebral cryo-sections after intravenous injection of THK-265 confirmed a systematic increase of the NIRF signal corresponding to Aβ plaque number and size during disease progression. "