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N- (1- methyl- 2- oxo- 1,2,3,4- tetrahydro- 7- quinolyl)- 2- ((2- methylpyrrolidin- 1- yl)methyl)biphenyl- 4- carboxamide

a Trpv1 channel antagonist; structure in first source

Also Known As:

AS 1928370; AS-1928370; AS1928370

Networked: 2 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aoki, Toshiaki: 2 articles (03/2011 - 01/2011)
2.	Kiso, Tetsuo: 2 articles (03/2011 - 01/2011)
3.	Matsuoka, Nobuya: 2 articles (03/2011 - 01/2011)
4.	Watabiki, Tomonari: 2 articles (03/2011 - 01/2011)
5.	Kakimoto, Shuichiro: 1 article (03/2011)
6.	Kohara, Atsuyuki: 1 article (03/2011)
7.	Kuramochi, Takahiro: 1 article (03/2011)
8.	Tsuji, Noriko: 1 article (03/2011)
9.	Yonezawa, Koichi: 1 article (03/2011)
10.	Tsukamoto, Mina: 1 article (01/2011)

Related Diseases

1.	Hyperalgesia 01/01/2011 - "Intrathecal administration of AS1928370 (30 µg/body) also significantly suppressed mechanical allodynia. " 01/01/2011 - "At lower oral doses (0.3-1.0 mg/kg), AS1928370 improved mechanical allodynia in mice undergoing spinal nerve ligation. " 01/01/2011 - "Intrathecal administration of AS1928370, a transient receptor potential vanilloid 1 antagonist, attenuates mechanical allodynia in a mouse model of neuropathic pain." 03/01/2011 - "AS1928370 improved capsaicin-induced secondary hyperalgesia and mechanical allodynia in an L5/L6 spinal nerve ligation model in rats with respective ED₅₀ values of 0.17 and 0.26 mg/kg p.o. "
2.	Neuralgia (Stump Neuralgia) 03/01/2011 - "Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect." 01/01/2011 - "Intrathecal administration of AS1928370, a transient receptor potential vanilloid 1 antagonist, attenuates mechanical allodynia in a mouse model of neuropathic pain." 01/01/2011 - "These results suggest that spinal TRPV1 has an important role in the transmission of neuropathic pain and that the central nervous system (CNS) penetrant TRPV1 receptor antagonist AS1928370 is a promising candidate for treating neuropathic pain." 01/01/2011 - "We previously showed that AS1928370, a novel TRPV1 antagonist that can prevent ligand-induced activation but not proton-induced activation, ameliorates neuropathic pain in rats without hyperthermic effect. "
3.	Acute Pain 01/01/2011 - "Pretreatment with AS1928370 significantly suppressed both capsaicin-induced acute pain and withdrawal response in hot plate test at 10-30 mg/kg per os (p.o.). "
4.	Pain (Aches) 03/01/2011 - "Furthermore, AS1928370 alleviated inflammatory pain in a complete Freund's adjuvant model at 10 mg/kg p.o. "

Related Drugs and Biologics

1.	Capsaicin (Zostrix)
2.	Protons (Proton)
3.	Ligands
4.	Dihydrotachysterol (AT 10)
5.	Freund's Adjuvant
6.	TRPV1 receptor

Related Therapies and Procedures

1.	Ligation