kusunokinin

11/27/2022 - "Synthetic trans-(±)-kusunokinin ((±)KU), a potential anticancer substance, was revealed to have an inhibitory effect on breast cancer. "
06/29/2022 - "Breast cancer cell proliferation and migration are inhibited by naturally extracted trans-(-)-kusunokinin. "
07/27/2021 - "We then verified the action of (±)-kusunokinin compared with neratinibon breast cancer cells (MCF-7). "
07/27/2021 - "Trans-(-)-kusunokinin, an anticancer compound, binds CSF1R with low affinity in breast cancer cells. "
09/05/2020 - "We further confirmed the antimigration effect of (-)-kusunokinin; the results show that this compound inhibited breast cancer cell (MCF-7) migration in a dose-dependent manner. "

09/05/2020 - "In this study, we investigated the cytotoxic effect of (-)-kusunokinin from Piper nigrum on cancer cells. "
09/05/2020 - "Therefore, (-)-kusunokinin becomes an intriguing candidate for cancer treatment as it provides a strong potency in cancer inhibition."
09/05/2020 - "For in vivo study, 7.0 mg/kg and 14.0 mg/kg of (-)-kusunokinin reduced tumor growth without side effects on body weight, internal organs and bone marrow. "
02/01/2022 - "Trans-(±)-kusunokinin has been previously reported to inhibit cell proliferation and induce cell apoptosis in various cancer cell types, including breast, colon and cholangiocarcinoma. "
09/05/2020 - "NMU-induced rat mammary tumors, an ER positive breast cancer model, were treated with (-)-kusunokinin. "

11/28/2022 - "Anticancer Activity of (±)-Kusunokinin Derivatives towards Cholangiocarcinoma Cells."
02/01/2022 - "Trans-(±)-kusunokinin has been previously reported to inhibit cell proliferation and induce cell apoptosis in various cancer cell types, including breast, colon and cholangiocarcinoma. "
09/05/2020 - "Natural and synthetic (-)-kusunokinin inhibited breast cancer, colon cancer and cholangiocarcinoma cells at the G2/M phase and induced apoptosis. "
09/01/2019 - "The result showed that (±)-kusunokinin and (±)-bursehernin represented the strongest growth inhibition against breast cancer (MCF-7) and cholangiocarcinoma (KKU-M213) cells with the IC50 values of 4.30 ± 0.65 μM and 3.70 ± 0.79 μM, respectively, both of which were lower than IC50 of normal fibroblast cells (L929). "
09/01/2019 - "In this study, (±)-kusunokinin and its derivative, (±)-bursehernin, were synthesized and investigated for their anticancer activities on cell viability, cell cycle arrest and apoptosis in cancer cell lines including breast cancer (MCF-7, MDA-MB-468 and MDA-MB-231), colon cancer (HT-29) and cholangiocarcinoma (KKU-K100, KKU-M213 and KKU-M055) cells. "

09/05/2020 - "Natural and synthetic (-)-kusunokinin inhibited breast cancer, colon cancer and cholangiocarcinoma cells at the G2/M phase and induced apoptosis. "
09/01/2019 - "In this study, (±)-kusunokinin and its derivative, (±)-bursehernin, were synthesized and investigated for their anticancer activities on cell viability, cell cycle arrest and apoptosis in cancer cell lines including breast cancer (MCF-7, MDA-MB-468 and MDA-MB-231), colon cancer (HT-29) and cholangiocarcinoma (KKU-K100, KKU-M213 and KKU-M055) cells. "

02/01/2022 - "In the present study, chemosensitive ovarian cancer cell line A2780 and chemoresistant ovarian cancer cell lines A2780cis, SKOV-3 and OVCAR-3 were treated with trans-(±)-kusunokinin to investigate its potential effects. "
02/01/2022 - "In conclusion, trans-(±)-kusunokinin suppressed ovarian cancer cells through the inhibition of colony formation, cell proliferation and the induction of apoptosis. "
02/01/2022 - "However, the potential effects of (±)-kusunokinin on ovarian cancer remains unknown. "
02/01/2022 - "Effects of trans-(±)-kusunokinin on chemosensitive and chemoresistant ovarian cancer cells."