PF-03732010 monoclonal antibody

11/01/2010 - "Multiple orthotopic and metastatic tumor models were used for assessing the antitumor and antimetastatic activities of PF-03732010. "
11/01/2010 - "In contrast, PF-03732010 did not show antitumor and antimetastatic efficacy in the counterpart tumor models exhibiting low P-cadherin expression. "
11/01/2010 - "In the P-cadherin-overexpressing tumor models, including MDA-MB-231-CDH3, 4T1-CDH3, MDA-MB-435HAL-CDH3, HCT116, H1650, PC3M-CDH3, and DU145, PF-03732010 inhibited the growth of primary tumors and metastatic progression, as determined by bioluminescence imaging. "
08/01/2012 - "Down-regulation of P-cadherin with PF-03732010 inhibits cell migration and tumor growth in gastric cancer."
11/01/2010 - "We characterized the biological properties of PF-03732010, a human monoclonal antibody against P-cadherin, in cell-based assays and tumor models. "

08/01/2012 - "Down-regulation of P-cadherin with PF-03732010 inhibits cell migration and tumor growth in gastric cancer."
08/01/2012 - "We also demonstrated that inhibition of P-cadherin by PF-03732010, a fully humanized anti-P-cadherin IgG1 monoclonal antibody, suppressed cell migration in vitro and tumor growth in BALB/c nude mice bearing SNU620 gastric cancer xenograft. "