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human MIRN425 microRNA

RefSeq NR_029948

Also Known As:

MIRN425 microRNA, human; MIRN425-5p microRNA, human; hsa-mir-425; miR-425, human; miR-425-5p, human; microRNA-425, human

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - RNA: 69704
    - Untranslated RNA: 2850
      - Small Untranslated RNA: 566
        MicroRNAs: 67298
        human MIRN425 microRNA: 2
    - Antisense RNA: 1599
      - MicroRNAs: 67298
        human MIRN425 microRNA: 2
- Antisense Elements (Genetics): 31
  - Antisense RNA: 1599
    - MicroRNAs: 67298
      - human MIRN425 microRNA: 2

Experts

1.	Jia, Erna: 1 article (05/2015)
2.	Li, Jiarui: 1 article (05/2015)
3.	Li, Jiayu: 1 article (05/2015)
4.	Sang, Haiyan: 1 article (05/2015)
5.	Si, Daoyuan: 1 article (05/2015)
6.	Su, Ziyuan: 1 article (05/2015)
7.	Zhou, Changyu: 1 article (05/2015)
8.	Agirre, X: 1 article (04/2013)
9.	Alvarez, S: 1 article (04/2013)
10.	Calasanz, M J: 1 article (04/2013)

Related Diseases

1.	Genetic Translocation (Chromosomal Translocation) 04/01/2013 - "We found that target genes of the most differentially expressed miRNAs are directly involved in the pathogenesis of MM; specifically, the inhibition of hsa-miR-425, hsa-miR-152 and hsa-miR-24, which are all downregulated in h-MM, leads to the overexpression of CCND1, TACC3, MAFB, FGFR3 and MYC, which are the also the oncogenes upregulated by the most frequent IgH chromosomal translocations occurring in nh-MM. Importantly, we showed that the downregulation of these specific miRNAs and the upregulation of their targets also occur simultaneously in primary cases of h-MM. These data provide further evidence on the unifying role of cyclin D pathways deregulation as the key mechanism involved in the development of both groups of MM. Finally, they establish the importance of miRNA deregulation in the context of MM, thereby opening up the potential for future therapeutic approaches based on this molecular mechanism."
2.	Obesity 05/01/2015 - "Moreover, hsa-miR-425 and hsa-miR-126 had a significant number of target genes and hsa-miR-16/COL12A1 and hsa-miR-634/SLC4A4 interaction pairs are significantly co-expressed, suggesting that they might play important roles in the pathogenesis of obesity. "

Related Drugs and Biologics

1.	Cyclin D
2.	MicroRNAs (MicroRNA)
3.	human MIRN152 microRNA
4.	human MIRN24 microRNA