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sarcosine- arginyl- valyl- tyrosyl- lysyl- histidyl- prolyl- alanine

a beta-arrestin biased ligand of the angiotensin II type 1 receptor that engages beta-arrestin2 recruitment

Also Known As:

Sar-Arg-Val-Tyr-Lys-His-Pro-Ala; TRV120023

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - sarcosine-arginyl-valyl-tyrosyl-lysyl-histidyl-prolyl-alanine: 3

Experts

1.	Violin, Jonathan D: 3 articles (07/2015 - 10/2012)
2.	Solaro, R John: 2 articles (07/2015 - 09/2013)
3.	Cowan, Conrad L: 1 article (07/2015)
4.	Davis, Robert T: 1 article (07/2015)
5.	Mungai, Paul T: 1 article (07/2015)
6.	Ryba, David M: 1 article (07/2015)
7.	Tarigopula, Madhusudhan: 1 article (07/2015)
8.	Wieczorek, David F: 1 article (07/2015)
9.	Wolska, Beata M: 1 article (07/2015)
10.	Henze, Marcus: 1 article (09/2013)

Related Diseases

1.	Cardiomegaly (Heart Hypertrophy) 09/15/2013 - "The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium." 09/15/2013 - "In the present study, we compared the cardioprotective effects of TRV120023, a novel angiotensin II (ANG II) type 1 receptor (AT1R) ligand, which blocks G protein coupling but stimulates β-arrestin signaling, against treatment with losartan, a conventional AT1R blocker in the treatment of cardiac hypertrophy and regulation of myofilament activity and phosphorylation. "
2.	Reperfusion Injury 10/15/2012 - "In response to cardiac injury induced by ischemia reperfusion injury or mechanical stretch, pretreatment with TRV120023 significantly diminishes cell death compared with losartan, which did not appear to be cardioprotective. "
3.	Hypertrophy 07/15/2015 - "Our previous work demonstrated that the biased ligand TRV120023 is able to block angiotensin-induced hypertrophy, while promoting an increase in sarcomere Ca(2+) response. "
4.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 07/15/2015 - "Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model."

Related Drugs and Biologics

1.	Losartan (Cozaar)
2.	Ligands
3.	Arrestin
4.	GTP-Binding Proteins (G-Protein)
5.	Angiotensin II
6.	Cardiac Myosins
7.	Calcium
8.	Angiotensins