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chrysotoxine

inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via mitochondria protection and NF-κB modulation; structure in first source

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Bibenzyls: 16
        chrysotoxine: 4

Experts

1.	Sritularak, Boonchoo: 2 articles (01/2020 - 01/2018)
2.	Shaw, Pang-Chui: 2 articles (07/2012 - 11/2010)
3.	Song, Ju-Xian: 2 articles (07/2012 - 11/2010)
4.	Sze, Cho-Wing: 2 articles (07/2012 - 11/2010)
5.	Tong, Yao: 2 articles (07/2012 - 11/2010)
6.	Yao, Xin-Sheng: 2 articles (07/2012 - 11/2010)
7.	Zhang, Yan-Bo: 2 articles (07/2012 - 11/2010)
8.	Böttcher, Chotima: 1 article (01/2020)
9.	Dehlinger, Adeline: 1 article (01/2020)
10.	Khoonrit, Pichayatri: 1 article (01/2020)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 11/01/2010 - "Chrysotoxine is thus a candidate for further evaluation of its protection against neurodegeneration in Parkinson's disease."
2.	Mitochondrial Diseases (Mitochondrial Disease) 07/11/2012 - "The overproduction of reactive oxygen species (ROS), mitochondrial dysfunction as indexed by the decrease in membrane potential, increase in calcium concentration and NF-κB activation triggered by MPP(+) were blocked by chrysotoxine pretreatment. " 11/01/2010 - "6-OHDA-induced intracellular generation of reactive oxygen species (ROS), activation of p38 MAPK and ERK1/2, and mitochondrial dysfunctions, including the decrease of membrane potential, increase of intracellular free Ca2+, release of cytochrome c, imbalance of Bax/Bcl-2 ratio and activation of caspase-3 were strikingly attenuated by chrysotoxine pretreatment. "
3.	Neoplasms (Cancer) 01/01/2018 - "Our findings indicate a novel CSC-targeted role of chrysotoxine and its regulation by Src/Akt and Sox2, which may be exploited for cancer treatment."
4.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "Dendrobium bibenzyls and phenanthrenes such as chrysotoxine, cypripedin, gigantol and moscatilin have been reported to show promising inhibitory effects on lung cancer growth and metastasis in ex vivo human cell line models, suggesting their potential for clinical application in patients with lung cancer. "
5.	Lung Neoplasms (Lung Cancer) 01/01/2020 - "Dendrobium bibenzyls and phenanthrenes such as chrysotoxine, cypripedin, gigantol and moscatilin have been reported to show promising inhibitory effects on lung cancer growth and metastasis in ex vivo human cell line models, suggesting their potential for clinical application in patients with lung cancer. "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Caspase 3 (Caspase-3)
3.	p38 Mitogen-Activated Protein Kinases
4.	Cytochromes c (Cytochrome c)
5.	Phenanthrenes
6.	Calcium
7.	Bibenzyls
8.	gigantol
9.	dendrophenol
10.	thiazolyl blue