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1,2- dideoxy- 2'- propylglucopyranoso(2,1- d)- delta 2'-thiazoline

inhibits O-GlcNAcase; structure in first source

Also Known As:

NButGT

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - 1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline: 4

Experts

1.	Macauley, Matthew S: 2 articles (09/2010 - 12/2008)
2.	Vocadlo, David J: 2 articles (09/2010 - 12/2008)
3.	Aillerie, Virginie: 1 article (12/2019)
4.	Bigot, Edith: 1 article (12/2019)
5.	Cadiet, Julien: 1 article (12/2019)
6.	Chatham, John C: 1 article (12/2019)
7.	Denis, Manon: 1 article (12/2019)
8.	Erraud, Angélique: 1 article (12/2019)
9.	Ferron, Marine: 1 article (12/2019)
10.	Gauthier, Chantal: 1 article (12/2019)

Related Diseases

1.	Insulin Resistance 09/24/2010 - "NButGT also does not affect the severity or onset of insulin resistance induced by a high-fat diet. " 09/24/2010 - "Treatment of rats and mice with NButGT, for various time regimens and doses, dramatically increases O-GlcNAc levels throughout all tissues but does not perturb insulin sensitivity or alter glucohomeostasis. " 12/12/2008 - "Here we address the potential link between elevated O-GlcNAc and insulin resistance by using a potent and selective inhibitor of O-GlcNAcase (NButGT (1,2-dideoxy-2'-propyl-alpha-D-glucopyranoso-[2,1-D]-Delta 2'-thiazoline), 1200-fold selectivity). "
2.	Shock 12/10/2019 - "Rats received lipopolysaccharide (LPS) to induce endotoxemic shock or saline (control) and fluid resuscitation (R) with or without O-GlcNAc stimulation (NButGT-10 mg/kg) 1 hour after shock induction. "
3.	Neuroinflammatory Diseases 01/01/2013 - "Moreover, NButGT attenuated the accumulation of Aβ, neuroinflammation, and memory impairment in the 5XFAD mice. "

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	hexosaminidase C

Related Therapies and Procedures

1.	Resuscitation