molibresib

mimicks acetylated histones; structure in first source

Also Known As:

2-((4S)-6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-4-yl)-N-ethylacetamide monobenzenesulfonate salt; GSK 525762A; GSK-525762A; GSK525762; GSK525762A; I-BET compound; I-BET762; IBET compound; molibresib besylate

Networked: 33 relevant articles (4 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        molibresib: 33

Experts

1.	Ferron-Brady, Geraldine: 5 articles (01/2022 - 04/2020)
2.	Wyce, Anastasia: 5 articles (01/2022 - 12/2013)
3.	Dhar, Arindam: 4 articles (01/2022 - 04/2020)
4.	Barbash, Olena: 4 articles (04/2020 - 12/2013)
5.	Chen, Chong: 4 articles (12/2016 - 06/2014)
6.	Cousin, Sophie: 2 articles (01/2022 - 04/2020)
7.	Foley, Shawn W: 2 articles (01/2022 - 04/2018)
8.	French, Christopher A: 2 articles (01/2022 - 04/2020)
9.	Hann, Christine L: 2 articles (01/2022 - 04/2020)
10.	Horner, Thierry: 2 articles (01/2022 - 04/2020)

Related Diseases

1.	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 01/01/2023 - "Part 2 (dose expansion) investigated the safety and efficacy of molibresib at the RP2D in patients with relapsed/refractory myelodysplastic syndrome (MDS; as well as AML evolved from antecedent MDS) or cutaneous T-cell lymphoma (CTCL). "
2.	Neuroblastoma 01/01/2020 - "Therefore, we examined the antitumor efficacy of combined BET/MEK inhibition utilizing I-BET726 or I-BET762 and trametinib in high-risk neuroblastoma. "
3.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/01/2023 - "Part 2 (dose expansion) investigated the safety and efficacy of molibresib at the RP2D in patients with relapsed/refractory myelodysplastic syndrome (MDS; as well as AML evolved from antecedent MDS) or cutaneous T-cell lymphoma (CTCL). "
4.	Hypersensitivity (Allergy) 01/01/2021 - "Intranasal administration of i-BET762 (BET inhibitor) or SAHA (HDAC inhibitor) attenuated thermal and mechanical hypersensitivity and this antiallodynic activity was improved by co-administration of both drugs. "
5.	Body Weight (Weight, Body) 01/01/2021 - "Covariate analysis indicated body weight had a significant effect on the volume of distribution of molibresib and GSK3529246, and higher levels of aspartate aminotransferase resulted in the lower clearance of GSK3529246. "

Related Drugs and Biologics

1.	Histone Deacetylase Inhibitors
2.	Mitogen-Activated Protein Kinase Kinases (MEKs)
3.	Aspartate Aminotransferases (Aspartate Transaminase)
4.	trametinib
5.	4- (1- acetyl- 4- ((4- chlorophenyl)amino)- 2- methyl- 1,2,3,4- tetrahydroquinolin- 6- yl)benzoic acid
6.	Nuclear Proteins (Protein, Nuclear)
7.	molibresib
8.	Proteins (Proteins, Gene)
9.	Estrogen Receptors
10.	Hormones (Hormone)

Related Therapies and Procedures

1.	Intranasal Administration
2.	Castration
3.	Craniotomy