N- (3,4- dimethoxyphenethyl)- N- methyl- 3- (3- pyridyl)- 2- propenamide

12/01/2010 - "These results suggest that TJN-331 is effective against IgA nephropathy in ddY mice and acts via suppression of TGF-β1 production in glomeruli."
12/01/2010 - "This study was performed to examine the antinephritic effects of TJN-331 in a mouse model of experimental IgA nephropathy. "
12/01/2010 - "Histopathological examination after both experimental periods showed that TJN-331 inhibited increases in the mesangial matrix index and the number of nuclei per glomerular cross-section, compared with in untreated ddY mice with IgA nephropathy. "

01/01/2010 - "Effect of TJN-331 on anti-Thy1 nephritis in rats via inhibition of transforming growth factor-β1 production."
01/01/2010 - "Next, we examined the effects of TJN-331 on rat anti-GBM nephritis induced by injection with anti-GBM serum. "
01/01/2010 - "To clarify the action of TJN-331 ((E)-N-(3,4-dimethoxyphenethyl)-N-methyl-3-(3-pyridyl)-2-propenamide) on TGF-beta1 production, glomeruli were isolated from rats with antiglomerular basement membrane (GBM) nephritis and incubated for 48 h with test drugs in vitro. "
01/01/2010 - "TJN-331 improves anti-glomerular basement membrane nephritis by inhibiting the production of intraglomerular transforming growth factor-beta1."
01/01/2010 - "This study was performed to examine the effects of the antifibrotic agents TJN-331 and tranilast on mesangial expansion in a rat model of anti-Thy1 nephritis. "

01/01/2010 - "The study of experimental glomerulonephritis in rats was performed to examine the antinephritic effects of TJN-331, a new herbally-derived chemical compound. "

01/01/2010 - "Administration of TJN-331, at a dose of 2 mg/kg/d, per os (p.o.), prevented proteinuria and increased crescent formation and adhesion of capillary walls to Bowman's capsule. "
01/01/2010 - "These results suggest that TJN-331 inhibits proteinuria and histopathological changes in glomeruli via suppression of TGF-beta1 production from inflamed glomeruli."